Chinese Journal of Antituberculosis ›› 2021, Vol. 43 ›› Issue (5): 516-520.doi: 10.3969/j.issn.1000-6621.2021.05.019
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FENG Bin-bin, JIN Feng, JING Hui, WANG Jun-ling, LIN Mei-ying, QIAO Xiu-li, LI Ming, QIU Li-hua()
Received:
2021-01-14
Online:
2021-05-10
Published:
2021-04-30
Contact:
QIU Li-hua
E-mail:Qiu-lh@163.com
FENG Bin-bin, JIN Feng, JING Hui, WANG Jun-ling, LIN Mei-ying, QIAO Xiu-li, LI Ming, QIU Li-hua. Identification and drug resistance of 439 clinical isolates of non-tuberculosis mycobacterium in Shandong[J]. Chinese Journal of Antituberculosis, 2021, 43(5): 516-520. doi: 10.3969/j.issn.1000-6621.2021.05.019
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特征 | 胞内分枝杆菌 (247例) | 堪萨斯分枝 杆菌(45例) | 脓肿分枝杆菌 (27例) | 其他分枝杆菌 (35例) | 合计 (354例) | χ2值 | P值 |
---|---|---|---|---|---|---|---|
性别 | 18.639 | <0.01 | |||||
男 | 166(67.21) | 36(80.00) | 9(33.33) | 19(54.29) | 230(64.97) | ||
女 | 81(32.79) | 9(20.00) | 18(66.67) | 16(45.71) | 124(35.03) | ||
年龄组(岁) | 42.363 | <0.01 | |||||
<45 | 19(7.69) | 16(35.56) | 8(29.63) | 11(31.43) | 54(15.25) | ||
45~60 | 90(36.44) | 19(42.22) | 8(29.63) | 10(28.57) | 127(35.88) | ||
61~90 | 138(55.87) | 10(22.22) | 11(40.74) | 14(40.00) | 173(48.87) |
药品 | 胞内分枝杆菌 (33株) | 堪萨斯分枝杆菌 (9株) | 偶发分枝杆菌 (4株) | 鸟分枝杆菌 (2株) | 龟分枝杆菌 (2株) | 合计 (50株) |
---|---|---|---|---|---|---|
异烟肼 | 32(96.97) | 7(7/9) | 4(4/4) | 2(2/2) | 2(2/2) | 47(94.00) |
利福平 | 33(100.00) | 2(2/9) | 4(4/4) | 2(2/2) | 2(2/2) | 43(86.00) |
链霉素 | 32(96.97) | 9(9/9) | 4(4/4) | 2(2/2) | 2(2/2) | 49(98.00) |
乙胺丁醇 | 20(60.61) | 0(0/9) | 4(4/4) | 1(1/2) | 1(1/2) | 26(52.00) |
卷曲霉素 | 32(96.97) | 7(7/9) | 4(4/4) | 2(2/2) | 2(2/2) | 47(94.00) |
左氧氟沙星 | 33(100.00) | 2(2/9) | 4(4/4) | 2(2/2) | 2(2/2) | 43(86.00) |
对氨基水杨酸 | 33(100.00) | 9(9/9) | 4(4/4) | 2(2/2) | 2(2/2) | 50(100.00) |
阿米卡星 | 31(93.94) | 9(9/9) | 4(4/4) | 2(2/2) | 2(2/2) | 48(96.00) |
卡那霉素 | 31(93.94) | 8(8/9) | 4(4/4) | 2(2/2) | 2(2/2) | 47(94.00) |
氧氟沙星 | 33(100.00) | 3(3/9) | 4(4/4) | 2(2/2) | 2(2/2) | 44(88.00) |
药品 | 胞内分枝杆菌 (84株) | 堪萨斯分枝杆菌 (14株) | 脓肿分枝杆菌 (24株) | 偶发分枝杆菌 (5株) | 其他分枝杆菌 (6株) | 合计 (133株) | χ2值 | P值 |
---|---|---|---|---|---|---|---|---|
利奈唑胺 | 69(82.14) | 1(7.14) | 0(0.00) | 0(0.0) | 2(2/6) | 72(54.14) | 67.821 | 0.000 |
克拉霉素 | 4(4.76) | 1(7.14) | 2(8.33) | 1(1/5) | 0(0.0) | 8(6.02) | - | 0.572a |
利福平 | 1(1.19) | 0(0.0) | 19(79.17) | 4(4/5) | 0(0.0) | 24(18.05) | - | 0.000a |
阿米卡星 | 1(1.19) | 1(7.14) | 2(8.33) | 0(0.0) | 1(1/6) | 5(3.76) | - | 0.125a |
亚胺培南/西司他丁 | 83(98.81) | 14(100.00) | 24(100.00) | 4(4/5) | 6(6/6) | 131(98.50) | - | 1.000a |
乙胺丁醇 | 34(40.48) | 6(42.86) | 24(100.00) | 3(3/5) | 2(2/6) | 69(51.88) | 27.104 | 0.000 |
头孢西丁 | 7(8.33) | 12(85.71) | 1(4.17) | 1(1/5) | 1(1/6) | 22(16.54) | - | 0.000a |
阿奇霉素 | 33(39.29) | 4(28.57) | 9(37.50) | 3(3/5) | 2(2/6) | 51(38.35) | 0.587 | 0.771 |
利福布汀 | 0(0.00) | 0(0.00) | 9(37.50) | 0(0.0) | 0(0.0) | 9(6.77) | - | 0.000a |
妥布霉素 | 24(28.57) | 11(78.57) | 23(95.83) | 5(5/5) | 5(5/6) | 68(51.13) | 39.968 | 0.000 |
加替沙星 | 54(64.29) | 2(14.29) | 20(83.33) | 0(0.0) | 5(5/6) | 81(60.90) | 18.402 | 0.000 |
莫西沙星 | 0(0.00) | 0(0.00) | 0(0.00) | 0(0.0) | 0(0.0) | 0(0.00) | ||
多西环素 | 79(94.05) | 13(92.86) | 22(91.67) | 4(4/5) | 4(4/6) | 122(91.73) | - | 0.858a |
米诺环素 | 81(96.43) | 10(71.43) | 21(87.50) | 4(4/5) | 4(4/6) | 120(90.23) | - | 0.006a |
复方磺胺甲噁唑 | 81(96.43) | 9(64.29) | 20(83.33) | 5(5/5) | 5(5/6) | 120(90.23) | - | 0.001a |
[1] | 曾旋, 陆坚, 徐字翔, 等. 非结核分枝杆菌菌种鉴定技术研究进展. 结核病与肺部健康杂志, 2019,8(2):146-148. doi: 10.3969/j.issn.2095-3755.2019.02.015. |
[2] | 全国第五次结核病流行病学抽样调查技术指导组, 全国第五次结核病流行病学抽样调查办公室. 2010年全国第五次结核病流行病学抽样调查报告. 中国防痨杂志, 2012,34(8):485-508. |
[3] | 沙巍. 重视非结核分枝杆菌病的规范化诊治. 中国防痨杂志, 2017,39(3):217-219. doi: 10.3969/j.issn.1000-6621.2017.03.001. |
[4] | 赵雁林, 逄宇. 结核病实验室检验规程. 北京: 人民卫生出版社,2015:58- 62, 83-86. |
[5] | 中华医学会结核病学分会, 《中华结核和呼吸杂志》编辑委员会. 非结核分枝杆菌病诊断与治疗专家共识. 中华结核和呼吸杂志, 2012,35(10):527-580. doi: 10.3760/cma.j.issn.1001-0939.2012.08.006. |
[6] | 唐神结, 高文. 临床结核病学.2版. 北京: 人民卫生出版社, 2019: 1026-1046. |
[7] |
Dakic'I, Arandjelovic'I, Savic'B, et al. Pulmonary isolation and clinical relevance of nontuberculous mycobacteria during nationwide survey in Serbia, 2010-2015. PLoS One, 2018,13(11):e0207751. doi: 10.1371/journal.pone.0207751.
doi: 10.1371/journal.pone.0207751 URL pmid: 30462740 |
[8] |
Hoefsloot W, van Ingen J, Andrejak C, et al. The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study. Eur Respir J, 2013,42(6):1604-1613. doi: 10.1183/09031936.00149212.
doi: 10.1183/09031936.00149212 URL |
[9] |
Pang Y, Tan Y, Chen J, et al. Diversity of nontuberculous mycobacteria in eastern and southern China: a cross-sectional study. Eur Respir J, 2017,49(3):1601429. doi: 10.1183/13993003.01429-2016.
doi: 10.1183/13993003.01429-2016 URL pmid: 28275172 |
[10] | Shao Y, Chen C, Song H, et al. The epidemiology and geographic distribution of nontuberculous mycobacteria clinical isolates from sputum samples in the eastern region of China. PLoS Neg Trop Dis, 2015,9(3):e0003623. doi: 10.1371/journal.pntd.0003623. |
[11] | 张洁, 苏建荣, 丁北川, 等. 北京地区非结核分枝杆菌菌种分布及耐药性研究. 中华结核和呼吸杂志, 2017,40(3):210-214. doi: 10.3760/cma.j.issn.1001-0939.2017.03.013. |
[12] |
Wu J, Zhang Y, Li J, et al. Increase in Nontuberculous Mycobacteria Isolated in Shanghai, China: Results from a Population-Based Study. PloS One, 2014,9(10):e109736. doi: 10.1371/journal.pone.0109736.
doi: 10.1371/journal.pone.0109736 URL pmid: 25330201 |
[13] |
Winthrop KL, Marras TK, Adjemian J, et al. Incidence and Prevalence of Nontuberculous Mycobacterial Lung Disease in a Large United States Managed Care Health Plan, 2008—2015. Ann Am Thorac Soc, 2020,17(2):178-185. doi: 10.1513/AnnalsATS.201804-2360C.
doi: 10.1513/AnnalsATS.201804-236OC URL pmid: 31830805 |
[14] |
Santin M, Barrabeig I, Malchair P, et al. Pulmonary Infections with Nontuberculous Mycobacteria, Catalonia,Spain,1994—2014. Emerg Infect Dis, 2018,24(6):1091-1094. doi: 10.3201/eid2406.172095.
doi: 10.3201/eid2406.172095 URL pmid: 29774836 |
[15] |
Tan Y, Su B, Shu W, et al. Epidemiology of pulmonary disease due to nontuberculous mycobacteria in Southern China, 2013—2016. BMC Pulm Med, 2018,18:1. doi: 10.1186/s12890-018-0728-z.
doi: 10.1186/s12890-017-0557-5 URL pmid: 29301525 |
[16] | 杨粟坤, 曹彦, 曹艳龙, 等. 结核病专科非结核分枝杆菌肺病菌种分布及病例特点研究. 中国人兽共患病学报, 2018,34(12):1137-1141. doi: 10.3969/j.issn.1002-2694.2018.00.198. |
[17] |
Zhang ZX, Cherng BP, Sng LH, et al. Clinical and microbiological characteristics of non-tuberculous mycobacteria diseases in Singapore with a focus on pulmonary disease, 2012—2016. BMC Infect Dis, 2019,19(1):436. doi: 10.1186/s12879-019-3909-3.
doi: 10.1186/s12879-019-3909-3 URL pmid: 31101082 |
[18] | 段鸿飞. 非结核分枝杆菌与疾病的相关性. 中国医刊, 2016,51(3):3-5. doi: 10. 3969/j. issn.1008-1070.2016. 03. 002. |
[19] | 宋华峰, 李声竹, 赵静, 等. 苏州地区非结核分枝杆菌的菌种鉴定和药敏相关性分析. 国际检验医学杂志, 2019,40(4):494-497. doi: 10.3969/j. issn.1673-4130.2019.04.030. |
[20] | 沈瑶杰, 刘伟, 金嘉琳, 等. 综合性医院非结核分枝杆菌临床分离株的菌种分布特征分析. 中华传染病杂志, 2017,35(10):580-584. doi: 10.3760/cma.j.issn.1000-6680.2017.10.002. |
[21] | 中华医学会结核病学分会. 非结核分枝杆菌病诊断与治疗指南(2020 年版). 中华结核和呼吸杂志, 2020,43(11):918-946. doi: 10.3760/cma.j.cn112147-20200508-00570. |
[22] | Daley CL, laccarino JM, Lange C, et al. Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline. Eur Respir J, 2020,56(1):200053. doi: 10.1183/13993003.00535-2020. |
[23] |
Haworth CS, Banks J, Capstick T, et al. British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD). Thorax, 2017, 72(Suppl 2): iil-i64. doi: 10.1136/thoraxjnl-2017-210927.
doi: 10.1136/thoraxjnl-2020-215107 URL pmid: 33859050 |
[24] |
Zhang Z, Pang Y, Wang Y, et al. Differences in risk factors and drug susceptibility between Mycobacterium avium and Mycobacterium intracellulare lung diseases in China. Int J Antimicrob Agents, 2015,45(5):491-495. doi: 10.1016/j.ijantimicag.2015.01.012.
doi: 10.1016/j.ijantimicag.2015.01.012 URL pmid: 25795316 |
[25] |
Wei G, Huang M, Wang G, et al. Antimicrobial susceptibility testing and genotyping of Mycobacterium avium isolates of two tertiary tuberculosis designated hospital, China. Infect Genet Evol, 2015,36:141-146. doi: 10.1016/j.meegid.2015.09.015.
doi: 10.1016/j.meegid.2015.09.015 URL pmid: 26391006 |
[26] |
Koh WJ, Jeon K, Shin SJ. Successful treatment of Mycobacterium massiliense lung disease with oral antibiotics only. Antimicrob Agents Chemother, 2013,57(2):1098-1100. doi: 10.1128/AAC.02016-12.
doi: 10.1128/AAC.02016-12 URL pmid: 23183432 |
[27] | 刘东鑫, 郑惠文, 贺文从, 等. 广州市非结核分枝杆菌临床分离株菌种鉴定及药物敏感性试验结果分析. 中国防痨杂志, 2019,41(5):534-540. doi: 10.3969/j.issn.1000-6621.2019.05.012. |
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