Chinese Journal of Antituberculosis ›› 2022, Vol. 44 ›› Issue (1): 64-70.doi: 10.19982/j.issn.1000-6621.20210545
• Original Articles • Previous Articles Next Articles
ZHANG Yang-ting1, LU Xue-zhao2, LI Xiao-na1, ZHONG Zhao-yi1, WANG Na3, CAI Jing1, MA Ai-guo1, LIU Yu-feng3(), WANG Qiu-zhen1()
Received:
2021-09-13
Online:
2022-01-10
Published:
2021-12-29
Contact:
LIU Yu-feng,WANG Qiu-zhen
E-mail:liuyufengqd@126.com;kevin_1971@126.com
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CLC Number:
ZHANG Yang-ting, LU Xue-zhao, LI Xiao-na, ZHONG Zhao-yi, WANG Na, CAI Jing, MA Ai-guo, LIU Yu-feng, WANG Qiu-zhen. Study on influencing factors of anti-tuberculosis drug-induced liver injury in pulmonary tuberculosis patients complicated with diabetes mellitus[J]. Chinese Journal of Antituberculosis, 2022, 44(1): 64-70. doi: 10.19982/j.issn.1000-6621.20210545
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URL: http://www.zgflzz.cn/EN/10.19982/j.issn.1000-6621.20210545
基本特征 | 肝损伤组(53例) | 无肝损伤组(405例) | χ2值 | P值 |
---|---|---|---|---|
年龄(岁) | 0.238 | 0.626 | ||
≥60 | 15(28.3) | 128(31.6) | ||
<60 | 38(71.7) | 277(68.4) | ||
性别 | 1.194 | 0.274 | ||
男性 | 43(81.1) | 351(86.7) | ||
女性 | 10(18.9) | 54(13.3) | ||
婚姻状况 | 0.164 | 0.686 | ||
已婚 | 45(84.9) | 352(86.9) | ||
未婚/离异/丧偶 | 8(15.1) | 53(13.1) | ||
文化水平 | 3.535 | 0.316 | ||
小学及以下 | 17(32.1) | 97(23.9) | ||
初中 | 17(32.1) | 143(35.3) | ||
高中/职专 | 9(17.0) | 106(26.2) | ||
大专/职大及以上 | 10(18.8) | 59(14.6) | ||
职业 | 2.065 | 0.559 | ||
家务/待业/退休 | 12(22.6) | 124(30.6) | ||
农民 | 6(11.4) | 36(8.9) | ||
工人 | 15(28.3) | 90(22.2) | ||
其他a | 20(37.7) | 155(38.3) | ||
吸烟 | 4.422 | 0.035 | ||
是 | 31(58.5) | 175(43.2) | ||
否 | 22(41.5) | 230(56.8) | ||
基本特征 | 肝损伤组(53例) | 无肝损伤组(405例) | χ2值 | P值 |
饮酒 | 5.486 | 0.019 | ||
是 | 33(62.3) | 183(45.2) | ||
否 | 20(37.7) | 222(54.8) | ||
体力活动水平 | 10.832 | 0.004 | ||
轻度 | 38(71.7) | 276(68.2) | ||
中等 | 9(17.0) | 117(28.9) | ||
重度 | 6(11.3) | 12(2.9) | ||
体质量指数 | 12.659 | 0.005 | ||
<18.5 | 13(24.5) | 35(8.6) | ||
18.5~ | 25(47.2) | 225(55.6) | ||
24.0~ | 12(22.6) | 118(29.1) | ||
≥28.0 | 3(5.7) | 27(6.7) | ||
痰涂片 | 5.886 | 0.208 | ||
阴性 | 16(30.2) | 114(28.1) | ||
+ | 8(15.1) | 75(18.5) | ||
2(3.8) | 46(11.4) | |||
+ | 3(5.7) | 38(9.4) | ||
24(45.2) | 132(32.6) | |||
患者类型 | 1.011 | 0.315 | ||
复治 | 12(22.6) | 69(17.0) | ||
初治 | 41(77.4) | 336(83.0) | ||
使用保肝药 | 0.002 | 0.969 | ||
是 | 42(79.2) | 320(79.0) | ||
否 | 11(20.8) | 85(21.0) | ||
保肝药使用种类 | 1.701 | 0.427 | ||
0种 | 11(20.8) | 85(21.0) | ||
1~2种 | 28(52.8) | 243(60.0) | ||
3种及以上 | 14(26.4) | 77(19.0) |
临床指标 | 肝损伤组(53例) | 无肝损伤组(405例) | 统计检验值 | P值 |
---|---|---|---|---|
结核病特征性表现[例(发生率,%)] | ||||
咳嗽 | 48(90.6) | 365(90.6) | χ2=0.000 | 1.000 |
咳痰 | 45(84.9) | 325(80.6) | χ2=0.556 | 0.456 |
咯血 | 8(15.1) | 53(13.2) | χ2=0.153 | 0.696 |
发热 | 19(35.8) | 141(35.0) | χ2=0.015 | 0.902 |
乏力 | 22(41.5) | 177(43.9) | χ2=0.111 | 0.739 |
盗汗 | 17(32.1) | 120(29.8) | χ2=0.118 | 0.731 |
胸痛 | 12(22.6) | 69(17.1) | χ2=0.977 | 0.323 |
食欲减退 | 10(18.9) | 51(12.7) | χ2=1.560 | 0.212 |
胸闷 | 22(41.5) | 184(45.7) | χ2=0.325 | 0.568 |
血脂异常[例(发生率,%)] | ||||
高甘油三酯血症 | 3(5.7) | 28(6.9) | χ2=0.117 | 0.733 |
高胆固醇血症 | 1(1.9) | 21(5.2) | χ2=1.115 | 0.291 |
混合型高脂血症 | 3(5.7) | 9(2.2) | χ2=2.171 | 0.141 |
低高密度脂蛋白血症 | 24(45.3) | 115(28.4) | χ2=6.323 | 0.012 |
总蛋白(g/L, | 66.00±7.69 | 66.71±7.25 | t=0.454 | 0.524 |
白蛋白(g/L, | 36.81±5.45 | 39.78±12.39 | t=3.144 | 0.099 |
低蛋白血症[例(发生率,%)] | 6(11.3) | 25(6.2) | χ2=1.968 | 0.161 |
贫血[例(发生率,%)] | 20(37.7) | 85(21.0) | χ2=7.440 | 0.006 |
空腹血糖a(mmol/L, | 12.36±4.67 | 9.45±3.52 | t=-4.184 | <0.001 |
血糖控制不良a[例(发生率,%)] | 40(83.3) | 260(68.2) | χ2=4.617 | 0.032 |
变量 | β值 | s | Wald χ2值 | P值 | HR(95%CI)值 |
---|---|---|---|---|---|
血糖控制不良 | 1.025 | 0.407 | 6.355 | 0.012 | 2.787(1.256~6.183) |
吸烟 | -0.432 | 0.344 | 1.570 | 0.210 | 0.649(0.331~1.276) |
饮酒 | 0.770 | 0.346 | 4.959 | 0.026 | 2.159(1.097~4.251) |
中/重体力活动 | -0.455 | 0.344 | 1.743 | 0.187 | 0.635(0.323~1.246) |
使用保肝药情况 | —0.432 | 0.405 | 1.140 | 0.286 | 0.649(0.294~1.435) |
消瘦(体质量指数<18.5) | 1.032 | 0.359 | 8.294 | 0.004 | 2.808(1.391~5.670) |
贫血 | 0.420 | 0.305 | 1.902 | 0.168 | 1.522(0.838~2.765) |
膳食多样性不足 | 1.163 | 0.432 | 7.244 | 0.007 | 3.199(1.372~7.459) |
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