Screening of latent infection of Mycobacterium tuberculosis and analysis of influencing factors in elderly patients with type-2 diabetic mellitus in Xuhui and Changning Districts in Shanghai

doi:10.19982/j.issn.1000-6621.20210579

Abstract

Abstract:

Objective: To investigate the screening and risk factors of latent tuberculosis infection (LTBI) in elderly patients with type-2 diabetic mellitus (DM) in Shanghai. Methods: According to inclusion criteria, 885 type-2 DM patients aged over 60 years old in Xuhui (n=430) and Changning Districts (n=455)were sequentially selected. All of them were participated in community physical examination of basic public health service program from September to December 2019. γ-interferon release test was conducted to detect LTBI. The demographics, life behavior, history of DM and other chronic diseases, and tuberculosis contact information, as well as physical examination results,etc., were collected by questionnaire. Dichotomous unconditional logistic regression were used to analyze the risk factors of LTBI in elderly type-2 DM patients. Results: Of the 885 patients, 130 were positive in LTBI test with the positive rate of 14.7%, and the positive rate in Changning District was significantly higher than that in Xuhui District (17.4% (75/430) vs. 12.1% (55/455),χ²=5.057, P=0.025). The positive rate in patients with smoking behavior was significantly higher than that in patients without smoking behavior (22.5% (20/89) vs. 13.8% (110/796), χ ²=4.783,P=0.039). According to logistic regression, smoking was a risk factor of LTBI in elderly type-2 DM patients (OR (95%CI)=1.891 (1.031-3.468)). Conclusion: The prevalence of LTBI in elderly type-2 DM patients in Shanghai is relatively lower. Follow up and health education should be strengthened to DM patients with LTBI. LTBI screening could be conducted in elderly DM patients with smoking behavior.

Key words: Aged, Diabetes mellitus,type 2, Latent tuberculosis, Epidemiologic studies, Shanghai

CLC Number:

R52
R183.3

CHEN Jing, XIAO Xiao, WU Zhe-yuan, RAO Li-xin, WANG Juan, ZHANG Xia, SHEN Xin, YUAN Zheng-an. Screening of latent infection of Mycobacterium tuberculosis and analysis of influencing factors in elderly patients with type-2 diabetic mellitus in Xuhui and Changning Districts in Shanghai[J]. Chinese Journal of Antituberculosis, 2022, 44(2): 181-186. doi: 10.19982/j.issn.1000-6621.20210579

Figures/Tables 2

References 22

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基础资料	患者例数	构成比(%)	基础资料	患者例数	构成比(%)
一般资料			同住亲属人数(名)
年龄组(岁)			独居	6	0.7
60~69	391	44.2	1~3	748	84.5
≥70	494	55.8	≥4	131	14.8
性别			糖尿病基本情况^a
女性	480	54.2	糖尿病患病年限(年)
男性	405	45.8	<10	504	56.9
文化程度			10~19	260	29.4
初中及以下	486	54.9	≥20	116	13.1
高中	266	30.1	空腹血糖(mmol/L)
大学及以上	133	15.0	<7.8	448	50.6
退休前职业			7.8~11.1	357	40.4
商业服务业	133	15.0	>11.1	80	9.0
技术人员	243	27.5	糖尿病家族史^a
工人/农民	498	56.3	无	499	56.4
无业	11	1.2	有	381	43.1
婚姻状况			参加年度体检^b
单身/离异/丧偶	101	11.4	否	119	13.4
在婚	784	88.6	是	764	86.3
体质量指数			接受年度胸部X线摄片检查^c
<18.5	13	1.5	否	300	33.9
18.5~23.9	368	41.6	是	582	65.8
≥24.0	504	56.9	肺结核患者接触史
医疗保险			无	859	97.1
无	2	0.2	有	26	2.9
上海	869	98.2
外地	14	1.6

特征	检测例数	阳性例数	阳性率(%)	χ²值	P值
性别				0.738	0.390
男性	405	64	15.8
女性	480	66	13.8
年龄组(岁)				1.514	0.219
60~69	391	51	13.0
≥70	494	79	16.0
文化程度				1.396	0.520
初中及以下	486	77	15.8
高中	266	37	13.9
大学及以上	133	16	12.0
退休前职业				2.510	0.473
商业服务业	133	14	10.5
技术人员	243	35	14.4
工人/农民	498	79	15.9
无业	11	2	18.2
同住亲属人数				1.068	0.834
独居	6	0	0.0
1~3	748	110	14.7
≥4	131	20	15.3
糖尿病患病年限(年)^a				3.386	0.184
<10	504	65	12.9
10~19	260	44	16.9
≥20	116	21	18.1
空腹血糖(mmol/L)				3.053	0.217
<7.8	448	62	13.8
7.8~11.1	357	51	14.3
>11.1	80	17	21.3
体质量指数				0.347	0.785
<18.5	13	2	15.4
18.5~23.9	368	51	13.9
>24.0	504	77	15.3
糖尿病家族史^a				0.334	0.563
无	499	75	15.0
有	381	52	13.6
肺结核接触史				0.010	0.919
无	859	126	14.7
有	26	4	15.4
吸烟				4.783	0.039
否	796	110	13.8
是	89	20	22.5
特征	检测例数	阳性例数	阳性率(%)	χ²值	P值
饮酒^b				1.442	0.255
否	797	113	14.2
是	84	16	19.0
经常到人流密集场所^c				0.144	0.879
否	780	117	15.0
是	96	13	13.5