Abstract:

Objective: To analyze the epidemiological characteristics of rifampicin drug-resistant tuberculosis in Foshan City through the routine surveillance data, and then provide a reference for formulating control and prevention strategies. Methods: The medical records of general tuberculosis patients, suspected drug-resistant and drug-resistant patients in the Tuberculosis Information Management System of Foshan City from 2011 to 2020 were cleaned and compiled to establish a comprehensive database. Drug resistance screening, pathogen identification and drug resistance detection were analyzed in different years from different sources, and the trend of resistance in different years was compared. Results: Among the registered pathogenic positive pulmonary tuberculosis patients in Foshan from 2011 to 2020, the pathogenic positive rate increased from 34.0% (1629/4788) in 2011 to 56.7% (1505/2655) in 2020, with an average annual increase rate of 5.8%. The overall drug resistance screening rate shows an upward trend year by year. By 2020, the drug resistance screening rate of registered pathogenic positive patients had reached 100.0% (1505/1505). From 2011 to 2020, the rifampicin resistance rates of newly treated patients, retreated patients and patients registered in previous years were 1.9% (95%CI: 1.7%-2.1%), 18.9% (95%CI: 17.6%-20.3%) and 24.4% (95%CI: 23.1%-25.8%) respectively. The rifampicin resistance rate of newly treated patients registered in the current year had been maintained at a relatively low level, and the rifampicin resistance rate of retreated patients had decreased from 14.6% (13/89) in 2019 to 2.9% (2/69) in 2020. Conclusion: Routine tuberculosis surveillance data can reflect the epidemic situation of rifampin resistant tuberculosis in Foshan city. The registration of tuberculosis patients in previous years is the focus of the next step in the prevention and control of drug-resistant tuberculosis.

Key words: Tuberculosis,pulmonary, Drug resistance, Rifampin, Epidemiologic studies