Chinese Journal of Antituberculosis ›› 2022, Vol. 44 ›› Issue (5): 442-449.doi: 10.19982/j.issn.1000-6621.20210659
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WU Ming-qi1, YAN Shi-chun2, LIU Yu-qin3, GUO Xin3, WANG Mei-jie1, TIAN Jing1, HOU Shao-ying1()
Received:
2021-11-18
Online:
2022-05-10
Published:
2022-05-04
Contact:
HOU Shao-ying
E-mail:hsy3982@163.com
Supported by:
CLC Number:
WU Ming-qi, YAN Shi-chun, LIU Yu-qin, GUO Xin, WANG Mei-jie, TIAN Jing, HOU Shao-ying. Plasma proteomics analysis of diabetic patients complicated with pulmonary tuberculosis by iTRAQ technology[J]. Chinese Journal of Antituberculosis, 2022, 44(5): 442-449. doi: 10.19982/j.issn.1000-6621.20210659
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特征 | DM-PTB组(16例) | DM组(16例) | 统计检验值 | P值 |
---|---|---|---|---|
年龄[岁,M(Q1,Q3)] | 52.50(43.25,65.50) | 56.50(46.00,63.50) | U=142.500 | 0.584 |
性别[例(构成比,%)] | - | 1.000 | ||
男性 | 9(56.3) | 8(50.0) | ||
女性 | 7(43.7) | 8(50.0) | ||
体质量指数 | 22.36±3.03 | 27.54±3.78 | t=-4.274 | <0.001 |
糖尿病病程(年, | 5.35±2.94 | 7.36±3.07 | t=-1.888 | 0.069 |
空腹血糖[mmol/L,M(Q1,Q3)] | 7.92(7.12,11.27) | 7.24(6.54,10.32) | U=104.000 | 0.366 |
使用胰岛素[例(构成比,%)] | - | 0.458 | ||
是 | 9(56.3) | 12(75.0) | ||
否 | 7(43.7) | 4(25.0) | ||
口服降糖药[例(构成比,%)] | - | 0.002 | ||
是 | 1(6.3) | 10(62.5) | ||
否 | 15(93.7) | 6(37.5) |
序号 | 基因 | 蛋白名称 | FC值 | P值 | 表达趋势 | ||||
---|---|---|---|---|---|---|---|---|---|
P02741 | CRP | C反应蛋白 | 5.22 | 0.019 | ↑ | ||||
P0DJI9 | SAA2 | 血清淀粉样蛋白A2 | 3.84 | 0.007 | ↑ | ||||
P02763 | ORM1 | α1酸性糖蛋白1 | 3.01 | 0.012 | ↑ | ||||
Q96IU4 | ABHD14B | α/β水解酶结构域蛋白14B | 2.53 | <0.001 | ↑ | ||||
Q9NP78 | ABCB9 | ATP结合盒式亚族B成员9 | 2.51 | 0.035 | ↑ | ||||
Q13126 | MTAP | S-甲基化-5'-腺苷磷酸化酶 | 2.25 | 0.023 | ↑ | ||||
P02679 | FGG | 纤维蛋白原γ链 | 2.15 | 0.029 | ↑ | ||||
P11226 | MBL2 | 甘露糖结合凝集素 | 2.12 | 0.012 | ↑ | ||||
P02675 | FGB | 纤维蛋白原β链 | 2.04 | 0.032 | ↑ | ||||
P02750 | LRG1 | 富亮氨酸α-2糖蛋白1 | 2.00 | <0.001 | ↑ | ||||
Q9P1F3 | ABRACL | Costars家族蛋白ABRACL | 0.44 | 0.021 | ↓ | ||||
Q9HBI1 | PARVB | β-parvin | 0.43 | 0.004 | ↓ | ||||
P12814 | ACTN1 | α-辅肌动蛋白1 | 0.42 | <0.001 | ↓ | ||||
P23284 | PPIB | 肽基-脯氨酰顺-反异构酶B | 0.42 | 0.010 | ↓ | ||||
P09104 | ENO2 | 烯醇化酶γ | 0.39 | 0.003 | ↓ | ||||
Q92686 | NRGN | 神经颗粒素 | 0.39 | 0.001 | ↓ | ||||
P62158 | CALM1 | 钙调蛋白 | 0.39 | 0.002 | ↓ | ||||
Q5VZ66 | JAKMIP3 | Janus激酶与微管相互作用蛋白3 | 0.39 | <0.001 | ↓ | ||||
P37802 | TAGLN2 | 转凝蛋白2 | 0.38 | 0.002 | ↓ | ||||
P62328 | TMSB4X | 胸腺肽β4 | 0.37 | 0.003 | ↓ |
序号 | 功能名称 | 富集差异蛋白数量 |
---|---|---|
细胞组成 | ||
GO:0043226 | 细胞器 | 240 |
GO:0005622 | 细胞内 | 229 |
GO:0043227 | 膜结合细胞器 | 229 |
GO:0044424 | 细胞内组分 | 228 |
GO:0005737 | 细胞质 | 224 |
GO:0005576 | 细胞外区 | 218 |
GO:0044444 | 细胞质组分 | 213 |
GO:0044421 | 胞外区组分 | 205 |
GO:0043229 | 胞内细胞器 | 202 |
GO:0005615 | 细胞外间隙 | 198 |
分子功能 | ||
GO:0005488 | 结合 | 249 |
GO:0005515 | 蛋白结合 | 225 |
GO:0043168 | 负离子结合 | 68 |
GO:0044877 | 蛋白复合体结合 | 64 |
GO:0042802 | 同一蛋白结合 | 63 |
GO:0036094 | 小分子结合 | 62 |
GO:0005102 | 信号受体结合 | 61 |
GO:0019899 | 酶结合 | 61 |
GO:0098772 | 分子功能调节器 | 59 |
GO:0097367 | 碳水化合物衍生物结合 | 57 |
生物过程 | ||
GO:0009987 | 细胞过程 | 253 |
GO:0065007 | 生物调节 | 222 |
GO:0050789 | 生物过程调节 | 216 |
GO:0050896 | 刺激反应 | 212 |
GO:0050794 | 细胞过程调节 | 208 |
GO:0051179 | 定位 | 182 |
GO:0051716 | 细胞刺激反应 | 167 |
GO:0032501 | 多细胞生物过程 | 160 |
GO:0051234 | 建立定位 | 154 |
GO:0006810 | 转运 | 153 |
序号 | 通路名称 | 富集差异蛋白数量 |
---|---|---|
hsa04510 | 黏着斑通路 | 22 |
hsa04151 | PI3K-Akt信号通路 | 17 |
hsa04810 | 肌动蛋白细胞骨架调节通路 | 15 |
hsa04611 | 血小板激活通路 | 14 |
hsa04015 | Rap1信号通路 | 12 |
hsa04512 | ECM受体交互作用 | 11 |
hsa01200 | 碳代谢通路 | 11 |
hsa04514 | 细胞黏着分子通路 | 11 |
hsa04145 | 吞噬体通路 | 11 |
hsa00010 | 糖酵解/糖异生通路 | 10 |
hsa05146 | 阿米巴通路 | 10 |
hsa04530 | 紧密连接通路 | 10 |
hsa04979 | 胆固醇代谢通路 | 9 |
hsa05100 | 上皮细胞细菌侵入通路 | 9 |
hsa05132 | 沙门菌感染通路 | 9 |
hsa04670 | 白细胞跨内皮迁移通路 | 9 |
hsa05130 | 致病性大肠杆菌感染通路 | 8 |
hsa05412 | 右心室心率失常心肌病通路 | 8 |
hsa04610 | 补体及凝血通路 | 8 |
hsa05410 | 肥厚性心机病通路 | 8 |
hsa05414 | 扩张性心肌病通路 | 8 |
hsa05131 | 志贺菌通路 | 7 |
hsa04520 | 黏着连接通路 | 7 |
hsa01230 | 氨基酸生物合成通路 | 7 |
hsa05020 | 朊病毒通路 | 6 |
hsa05144 | 疟疾通路 | 6 |
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