Analysis of the therapeutic effect of probiotics combined with enteral nutrition on patients with comorbidity of tuberculosis and type 2 diabetes with malnutrition

doi:10.3969/j.issn.1000-6621.2021.10.010

Abstract

Abstract:

Objective To assess the effects of probiotics combined with enteral nutrition on patients with comorbidity of pulmonary tuberculosis-type 2 diabetes mellitus (PTB-T2DM) with malnutrition. Methods Since January 5, 2018, patients with PTB-T2DM and malnutrition admitted in Hunan Chest Hospital were randomly allocated in observation group and control group using random number table. By December 15, 2020, 150 patients were enrolled in the study, 75 in the observation group (age: (60.8±8.6) years) and 72 in the control group (age: (57.9±10.6) years).The control group was treated with conventional anti-tuberculosis treatment, hypoglycemic diet and low GI enteral nutrition solution; the observation group was prescribed with probiotics additionally. Hemoglobin (Hb), albumin (Alb) and body mass index (BMI) were assessed before and after 14 days’ nutritional treatment. The occurrences of gastrointestinal adverse reactions such as nausea and vomiting during the nutritional treatment of those two groups were observed. Results After 14 days’ nutritional treatment, a significantly higher proportion of patients in the observation group had meaningful clinical response than in the control group based on the Hb, Alb and BMI ((104.69±16.37) g/L, (32.80±6.76) g/L and 19.23±3.04 vs (100.80±15.59) g/L, (32.44±4.77) g/L and 20.38±3.11, t values were 2.667, 2.023, 2.288, and P values were 0.008, 0.046, 0.023, respectively). The incidence of abdominal distension, diarrhea and constipation were lower in the observation group compared with the control group (5.33% (4/75), 2.67% (2/75) vs 18.06% (13/72), 12.50% (9/72), respectively, χ² of abdominal distension and constipation were 5.841 and 5.131, P values were 0.016, 0.024, respectively). The incidence of diarrhea was using performed by Fisher’s exact test, it shown that the observation group had lower incidence than control group (1.33% (1/75) vs 9.72% (7/72)). Conclusion Probiotics combined with enteral nutrition can significantly improve the nutritional status and prognosis of PTB-T2DM patients with malnutrition.

Key words: Tuberculosis, pulmonary, Diabetes mellitus, type 2, Nutritional assessment, Probiotics, Comparative study

TANG Han-mei, ZHANG Sheng-kang, YAN Mi, YUAN Dan, CAO Han-juan, ZHANG Xiao-bing, BAI Li-qiong, YI Heng-zhong, TANG Xi-liang. Analysis of the therapeutic effect of probiotics combined with enteral nutrition on patients with comorbidity of tuberculosis and type 2 diabetes with malnutrition[J]. Chinese Journal of Antituberculosis, 2021, 43(10): 1027-1031. doi: 10.3969/j.issn.1000-6621.2021.10.010

Figures/Tables 2

References 21

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观察指标	观察组(75例)		t值	P值	对照组(72例)		t值	P值
观察指标	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
血红蛋白(g/L,$\bar{x}\pm s$)	97.99±17.15	104.69±16.37	5.024	0.000	98.12±15.86	100.80±15.59	3.234	0.002
血清白蛋白(g/L,$\bar{x}\pm s$)	30.61±4.88	32.80±6.76	3.952	0.000	31.47±5.20	32.44±4.77	3.137	0.002
血清总蛋白(g/L,$\bar{x}\pm s$)	58.91±6.28	61.39±6.92	4.342	0.000	58.83±5.86	61.08±5.96	4.273	0.000
体质量指数($\bar{x}\pm s$)	18.98±3.10	19.23±3.04	4.957	0.000	20.16±2.94	20.38±3.11	0.975	0.329

组别	例数	腹胀 [例,发生率(%)]	腹泻 [例,发生率(%)]	便秘 [例,发生率(%)]	恶心 [例,发生率(%)]	呕吐 [例,发生率(%)]
对照组	72	13(18.06)	7(9.72)	9(12.50)	6(8.33)	2(2.78)
观察组	75	4(5.33)	1(1.33)	2(2.67)	3(4.00)	0(0.00)
χ²值		5.841	-	5.131	1.200	-
P值		0.016	0.031	0.024	0.227	0.238