Comparative study on results of T-cell spot test for tuberculosis infection of peripheral blood and pleural effusion in tuberculous pleurisy patients complicated with type 2 diabetes mellitus

doi:10.19982/j.issn.1000-6621.20210642

Abstract

Abstract:

Objective: To investigate the effect of type 2 diabetes mellitus on the results of T-cell spot test for tuberculosis infection (T-SPOT.TB) of the peripheral blood and pleural effusion in patients with tuberculous pleurisy. Methods: According to whether complicated with type 2 diabetes mellitus, 444 tuberculous pleurisy patients from Xi’an Chest Hospital between 2016 and 2021 were divided into tuberculous pleurisy complicated with type 2 diabetes mellitus group (n=116) and tuberculous pleurisy without type 2 diabetes mellitus group (n=328). The pleural effusion and peripheral blood specimens of the two groups before medical treatment were collected for T-SPOT.TB, and the results were compared. Results: The positive rates of peripheral blood T-SPOT.TB were 46.55% (54/116) in the tuberculous pleurisy complicated with type 2 diabetes mellitus group and 56.10% (184/328) in the tuberculous pleurisy without type 2 diabetes mellitus group, respectively, and there was no significant difference between the two groups (χ²=3.140, P=0.076). The positive rate of pleural effusion T-SPOT.TB in the tuberculous pleurisy complicated with type 2 diabetes mellitus group was significantly lower than that in the tuberculous pleurisy without type 2 diabetes mellitus group (65.52% (76/116) vs. 88.41% (290/328), χ²=31.025, P<0.001). By T-SPOT.TB, the positive rates in pleural effusion were significantly higher than those in peripheral blood in both two groups (χ²=4.845, P=0.028; χ²=12.848, P<0.001). Conclusion: When tuberculous pleurisy patients complicated with type 2 diabetes mellitus, the positive rate of T-SPOT.TB in pleural effusion was decreased, but it was still higher than that in peripheral blood. Pleural effusion T-SPOT.TB detection was recommended to improve the positive detection rate.

Key words: Diabetes mellitus,type 2, Tuberculosis,pleural, Comorbidity, Enzyme-linked immunosorbent assay, Comparative study

CLC Number:

R52
R446.1

LIU Yuan, JU Meng, ZUO Lei, ZHANG Yao-hui, HUANG Yi. Comparative study on results of T-cell spot test for tuberculosis infection of peripheral blood and pleural effusion in tuberculous pleurisy patients complicated with type 2 diabetes mellitus[J]. Chinese Journal of Antituberculosis, 2022, 44(5): 489-493. doi: 10.19982/j.issn.1000-6621.20210642

Figures/Tables 1

特征	合并糖尿病组(116例)	非糖尿病组(328例)	统计检验值	P值
年龄(岁, $x ¯$ ±s)	58.0±14.5	34.5±16.9	t=13.331	<0.001
性别[例(构成比,%)]			χ²=3.183	0.074
男性	69(59.48)	225(68.60)
女性	47(40.52)	103(31.40)
合并肺结核[例(构成比,%)]			χ²=0.412	0.521
是	95(81.90)	277(84.45)
否	21(18.10)	51(15.55)
肺结核病原学结果[例(构成比,%)]			χ²=0.500	0.480
阳性	70(73.68)	214(77.26)
阴性	25(26.32)	63(22.74)
治疗情况[例(构成比,%)]			χ²=0.744	0.388
初治	83(71.55)	248(75.61)
复治	33(28.45)	80(24.39)
诊断依据[例(构成比,%)]			χ²=3.056	0.080
确诊	93(80.17)	285(86.89)
临床诊断	23(19.83)	43(13.11)

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