Epidemiological characteristics of MTB/HIV double infection in Changsha from 2011 to 2020

doi:10.19982/j.issn.1000-6621.20220040

Abstract

Abstract:

Objective: To analyze the epidemic characteristics of MTB/HIV double infection in Changsha, and to improve the prevention and control strategies. Methods: The data of MTB/HIV dual infection patients in Changsha from 2011 to 2020 were extracted from Tuberculosis Information Management System and TB/HIV Dual Infection Prevention and Management Annual Report, to establish a comprehensive database of MTB/HIV characteristics and distribution in Changsha. The detection of MTB/HIV dual infection, description of the annual change trend and the epidemic distribution characteristics in different time, gender, age and region were analyzed. Results: From 2011 to 2020, a total of 280 MTB/HIV double infection cases were found in Changsha, the patient detection rate fluctuated with the year (4.29% (12/280)-15.36% (43/280)). Among them, HIV infection were detected in 39 tuberculosis patients, with an annual detection rate of 0.10% (39/38990). The HIV positive rate showed an increasing trend of fluctuation in different years (0.03% (1/3759)-0.22% (9/4057))(Z=2.347, P=0.019). Among HIV/AIDS patients, MTB infection were detected in 241 cases, and the average annual detection rate was 0.68% (241/35381). The detection rate of tuberculosis showed a decreasing trend with fluctuation in different years (0.41% (19/4639)-2.13% (13/610))(Z=-6.126,P=0.001). The 280 MTB/HIV dual infected patients were mainly male (85.71% (240/280)); and the age was mainly at 25-44 years (46.78% (131/280)), followed by 45-64 years old (32.50% (91/280)). As to regional distribution, Liuyang City had the most cases (26.07% (73/280)), followed by Changsha County and Ningxiang City (both 16.43% (46/280)). Conclusion: The level of MTB/HIV double infection in Changsha was low, but the average annual detection rate of HIV infection among tuberculosis patients showed a fluctuating upward trend. The detection rate of MTB infection in HIV/AIDS screening showed a fluctuating downward trend. The prevention and control should be focused on male and 25-44 years age group, as well as people in areas with high prevalence of AIDS and tuberculosis.

Key words: Mycobacterium,tuberculosis, HIV Infections, Comorbidity, Epidemiologic study characteristics as topic

CLC Number:

XIONG Zi, XIE Ci-fu, SONG Li-xin, WANG Xiao-jun, TIAN Bin, HUANG Zhu-lin, XU Zu-hui, ZHANG Xi-xing, BAI Li-qiong. Epidemiological characteristics of MTB/HIV double infection in Changsha from 2011 to 2020[J]. Chinese Journal of Antituberculosis, 2022, 44(5): 484-488. doi: 10.19982/j.issn.1000-6621.20220040

Figures/Tables 3

References 24

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年份	结核病患者			HIV/AIDS者
年份	登记例数	HIV抗体检测例数 (检测率,%)	HIV抗体阳性例数 (检出率,%)	随访例数	结核病筛查例数 (筛查率,%)	诊断结核病例数 (检出率,%)
2011	5162	2086(40.41)	1(0.05)	926	610(65.87)	13(2.13)
2012	5042	2900(57.52)	3(0.10)	1084	1066(98.34)	9(0.84)
2013	5251	3759(71.59)	1(0.03)	1550	1548(99.87)	16(1.03)
2014	5057	4186(82.78)	2(0.05)	2181	2179(99.91)	37(1.70)
2015	4592	4177(90.96)	5(0.12)	2991	2903(97.06)	25(0.86)
2016	4618	4330(93.76)	3(0.07)	3762	3719(98.86)	25(0.67)
2017	4729	4155(87.86)	2(0.05)	4659	4639(99.57)	19(0.41)
2018	4455	4057(91.07)	9(0.22)	5517	5514(99.95)	26(0.47)
2019	4916	4728(96.18)	4(0.08)	6224	6197(99.57)	39(0.63)
2020	4795	4612(96.18)	9(0.20)	7061	7006(99.22)	32(0.46)
合计	48617	38990(80.20)	39(0.10)	35955	35381(98.40)	241(0.68)

年份	合计	性别		年龄组(岁)
年份	合计	男性	女性	≤24	25~44	45~64	≥65
2011	14(5.00)	13(92.86)	1(7.14)	0(0.00)	11(78.57)	3(21.43)	0(0.00)
2012	12(4.29)	10(83.33)	2(16.67)	2(16.67)	6(50.00)	4(33.33)	0(0.00)
2013	17(6.07)	12(70.59)	5(29.41)	1(5.88)	12(70.59)	4(23.53)	0(0.00)
2014	39(13.93)	32(82.05)	7(17.95)	9(23.08)	21(53.84)	9(23.08)	0(0.00)
2015	30(10.71)	29(96.67)	1(3.33)	0(0.00)	10(33.33)	17(56.67)	3(10.00)
2016	28(10.00)	22(78.57)	6(21.43)	0(0.00)	16(57.14)	10(35.72)	2(7.14)
2017	21(7.50)	18(85.71)	3(14.29)	1(4.76)	10(47.62)	7(33.33)	3(14.29)
2018	35(12.50)	30(85.71)	5(14.29)	8(22.86)	13(37.14)	4(11.43)	10(28.57)
2019	43(15.36)	39(90.70)	4(9.30)	4(9.30)	18(41.86)	15(34.89)	6(13.95)
2020	41(14.64)	35(85.37)	6(14.63)	4(9.76)	14(34.15)	18(43.90)	5(12.19)
总计	280(100.00)	240(85.71)	40(14.29)	29(10.36)	131(46.78)	91(32.50)	29(10.36)

年份	芙蓉区	天心区	岳麓区	开福区	雨花区	长沙县	望城区	宁乡市	浏阳市
2011	3(21.43)	2(14.29)	1(7.14)	3(21.43)	2(14.29)	1(7.14)	0(0.00)	1(7.14)	1(7.14)
2012	0(0.00)	0(0.00)	0(0.00)	0(0.00)	0(0.00)	7(58.33)	1(8.33)	0(0.00)	4(33.34)
2013	1(5.88)	0(0.00)	0(0.00)	0(0.00)	4(23.53)	1(5.88)	3(17.65)	3(17.65)	5(29.41)
2014	1(2.56)	1(2.56)	2(5.13)	8(20.51)	0(0.00)	2(5.13)	6(15.39)	13(33.33)	6(15.39)
2015	1(3.33)	0(0.00)	1(3.33)	2(6.68)	0(0.00)	6(20.00)	3(10.00)	1(3.33)	16(53.33)
2016	1(3.57)	0(0.00)	0(0.00)	4(14.29)	0(0.00)	6(21.43)	5(17.85)	4(14.29)	8(28.57)
2017	2(9.52)	0(0.00)	2(9.52)	3(14.29)	1(4.76)	7(33.34)	1(4.76)	2(9.52)	3(14.29)
2018	7(20.00)	1(2.86)	1(2.86)	9(25.71)	0(0.00)	4(11.43)	2(5.71)	5(14.29)	6(17.14)
2019	1(2.33)	3(6.98)	4(9.30)	3(6.98)	0(0.00)	8(18.60)	1(2.33)	8(18.60)	15(34.88)
2020	3(7.32)	2(4.88)	3(7.31)	4(9.76)	0(0.00)	4(9.76)	7(17.07)	9(21.95)	9(21.95)
合计	20(7.14)	9(3.21)	14(5.00)	36(12.86)	7(2.50)	46(16.43)	29(10.36)	46(16.43)	73(26.07)