Analysis of the control and prevention of MTB/HIV coinfection in Hefei from 2014 to 2019

doi:10.3969/j.issn.1000-6621.2021.08.009

Abstract

Abstract:

Objective To analyze the control and prevention effects of Mycobacterium tuberculosis and human immunodeficiency virus (MTB/HIV) coinfection in Hefei, and to provide scientific basis for the control and prevention of MTB/HIV coinfection in Hefei. Methods From 2014 to 2019, the AIDS Prevention and Control Department of each district (county) Center for Disease Control and Prevention (CDC) in Hefei referred HIV/AIDS patients to local tuberculosis designated hospitals for chest X-ray examination (chest X-ray). All of 2084 newly diagnosed HIV/AIDS patients and 8326 previous HIV/AIDS patients were screened for tuberculosis. Tuberculosis patients were tested for HIV antibody in designated TB hospitals, and those confirmed positive HIV antibody patients were referred to the AIDS Prevention Department of CDC for treatment. A total of 18146 TB patients registered from 2014 to 2019 were tested for HIV antibody. Results From 2014 to 2019, 2137 new HIV/AIDS patients were detected, among whom 2084 were screened for tuberculosis, and the screening rate was 97.52%. Twenty-four tuberculosis patients were detected, and the detection rate was 1.15% (24/2084). Among 8326 previous HIV/AIDS patients, 37 tuberculosis patients were detected. The HIV antibody test rates from 2014 to 2019 were 60.72% (2806/4621), 60.86% (2676/4397), 63.84% (2770/4339), 75.16% (3128/4162), 84.41% (3638/4310) and 82.42% (3128/3795). The HIV antibody test rate showed an upward trend in 6 years, and the difference was statistically significant (χ²_trend=1068.000, P=0.000). Twelve patients with positive HIV antibody were detected in 18146 tuberculosis patients, and the detection rate was 0.07%. Conclusion The detection rate of tuberculosis among newly-detected HIV/AIDS patients in Hefei is relatively high. To improve the tuberculosis screening rate of newly detected HIV/AIDS patients, and realize the sharing of tuberculosis and AIDS data and information, in order to achieve early detection and treatment of MTB/HIV coinfected patients, reduce the mortality of coinfected patients, and effectively control the MTB/HIV epidemic in Hefei.

Key words: Tuberculosis, HIV infection, Acquired immune deficiency syndrome, Comorbidity phenomenon

CAO Hong, DENG Xiao-lan, QIAN Bing, ZHANG Jie-ying, CHEN Wei. Analysis of the control and prevention of MTB/HIV coinfection in Hefei from 2014 to 2019[J]. Chinese Journal of Antituberculosis, 2021, 43(8): 803-807. doi: 10.3969/j.issn.1000-6621.2021.08.009

Figures/Tables 3

年份	结核病患者登记例数	HIV抗体检测		HIV抗体阳性
年份	结核病患者登记例数	例数	检测率(%)	例数	检出率(%)
2014	4621	2806	60.72	0	0.00
2015	4397	2676	60.86	2	0.07
2016	4339	2770	63.84	3	0.11
2017	4162	3128	75.16	3	0.10
2018	4310	3638	84.41	4	0.11
2019	3795	3128	82.42	0	0.00
$χ 趋势 2$ 值			1068.000		0.056
P值			0.000		0.813

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年份	新检出HIV抗体阳性患者					既往HIV抗体阳性患者					χ²值^a	P值^a	χ²值^b	P值^b
年份	登记例数	拍摄胸片例数	胸片检查率 (%)	检出结核病例数	结核病检出率 (%)	登记例数	拍摄胸片例数	胸片检查率 (%)	检出结核病例数	结核病检出率 (%)	χ²值^a	P值^a	χ²值^b	P值^b
2014	251	237	94.42	3	1.27	650	642	98.77	2	0.31	14.364	0.000	-^c	0.125
2015	330	321	97.27	4	1.25	870	866	99.54	14	1.62	9.461	0.002	0.039	0.844
2016	381	367	96.33	1	0.27	1165	1163	99.83	11	0.95	31.060	0.000	0.875	0.349
2017	371	368	99.19	8	2.17	1506	1501	99.67	3	0.20	0.668	0.414	16.455	0.000
2018	396	386	97.47	1	0.26	1851	1850	99.95	2	0.11	35.979	0.000	-^c	0.434
2019	408	405	99.26	7	1.73	2304	2304	100.00	5	0.22	-^c	0.003	14.579	0.000

年份	结核病患者中 MTB/HIV双重感染患者		结核病患者中非MTB/HIV双重感染患者		MTB/HIV 双重感染患者发现例数	《结核病信息管理系统》登记的MTB/HIV 双重感染者		MTB/HIV 双重感染患者治疗例数	MTB/HIV双重感染患者成功治疗
年份	例数	构成比(%)	例数	构成比(%)	MTB/HIV 双重感染患者发现例数	例数	率(%)	MTB/HIV 双重感染患者治疗例数	例数	率(%)
2014	5	0.11	4616	99.89	5	5	100.00	5	4	80.00
2015	20	0.45	4378	99.55	20	19	95.00	19	18	94.74
2016	15	0.35	4325	99.65	15	14	93.33	14	13	92.86
2017	14	0.34	4153	99.66	14	9	64.29	9	8	88.89
2018	7	0.16	4304	99.84	7	6	85.71	6	6	100.00
2019	12	0.32	3786	99.68	12	9	75.00	9	9	100.00