巨噬细胞功能相关的易感基因多态性与结核病相关性的研究进展

doi:10.3969/j.issn.1000-6621.2014.05.017

摘要/Abstract

摘要： 宿主巨噬细胞的功能状态将影响Mtb感染后的不同结局，不同个体之间巨噬细胞功能的差异并非只是免疫系统自身调节的结果，还与巨噬细胞功能相关基因的多态性有关，包括影响巨噬细胞杀伤能力的基因、影响巨噬细胞活化能力的基因、影响巨噬细胞凋亡水平的基因等。对巨噬细胞功能相关的易感基因多态性与肺结核易感性的相关性研究所取得的成果进行综述，结果显示：部分巨噬细胞功能相关的易感基因多态性与结核病易感性具有相关性，而且这种相关性不仅存在种族差异，还与结核病的临床类型有关。

关键词: 巨噬细胞, 多态现象, 遗传, 结核/遗传学, 疾病遗传易感性

Abstract: The function of the host macrophage causes different outcomes after Mycobacterium tuberculosis (Mtb) infection. The differences of the function of macrophage among individuals are not only the results of self-regulation in immune system, but also associated with the polymorphisms of susceptibility genes associated with the function of macrophage, including the genes influencing the killing, activation, apoptosis and other abilities of macrophage. This article reviews some achievements about the correlation between the polymorphism of susceptibility genes associated with the function of macrophage and pulmonary tuberculosis. The result shows partial polymorphism of susceptibility genes associated with the function of macrophage is correlated with the susceptibility to tuberculosis, and this correlation has not only ethical difference, but also is related to the clinical types of tuberculosis.

Key words: Macrophages, Polymorphism, genetic, Tuberculosis/genetics, Genetic predisposition to disease

江道斌，齐曼古力·吾守尔. 巨噬细胞功能相关的易感基因多态性与结核病相关性的研究进展[J]. 中国防痨杂志, 2014, 36(5): 385-387. doi: 10.3969/j.issn.1000-6621.2014.05.017

JIANG Dao-bin,Qimanguli WUSHOUER. Research progress of correlation between the polymorphisms of susceptibility genes associated with the function of macrophage and tuberculosis[J]. Chinese Journal of Antituberculosis, 2014, 36(5): 385-387. doi: 10.3969/j.issn.1000-6621.2014.05.017

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