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中国防痨杂志 ›› 2006, Vol. 28 ›› Issue (4): 247-249.

• 论著 • 上一篇    下一篇

影响肺结核治疗转归的因素分析

刘凤仁1;叶临湘1*;梁享生2;李振东2;   

  1. 1.华中科技大学同济医学院 武汉 430030;2.湖南省涟源市疾病预防控制中心 涟源 417100;
  • 出版日期:2006-04-10 发布日期:2006-11-03

Analysis on factors influencing the treatment outcome of tuberculosis patients.

Liu Fengren1,Ye Linxiang,LiangXiangsheng,et al.   

  1. 1.Department of Epiderniology and Statistic at Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
  • Online:2006-04-10 Published:2006-11-03

摘要: 目的分析影响肺结核患者治疗转归的有关因素,为结核病防治提供理论依据。方法收集1993—2001年世界银行贷款结核病控制项目期间涟源市卫生防疫站4 747份肺结核病历资料,对影响肺结核患者治疗转归的有关因素进行单因素分析和多因素非条件Logistic回归分析。结果单因素分析表明,年龄、性别、疾病治疗之初有咯血症状(χ2=10.20,P=0.01)及临床症状超过3种、合并其他结核、就诊延误、既往用药、空洞、非全程督导管理方式、治疗2个月末痰菌阳性、初治涂阳病人不含链霉素治疗方案对肺结核患者的治疗转归有影响。多因素分析结果显示:治疗之初痰菌阳性及乏力症状为促进患者治愈的有利因素;治疗初相关临床症状及体征如发热、肺部空洞的存在非全程督导为影响肺结核患者治疗转归的不利因素。结论加强宣传教育以减少患者的就诊延误现象,提高对结核病患者的全程督导率,提高患者正确服药依从性将有利于患者的预后。

关键词: 结核,肺, 治疗, 因素分析

Abstract: Objective To analyze the factors influencing on the treatment outcome of pulmonary tuberculosis(TB) patients and to provide evidence for TB prevention and control. Methods The data of 4 747 cases in Lianyuan Disease Control and Prevention Station from 1993 to 2001 were collected to analyze the factors influencing the treatment outcome of TB patients by using Chi square test and unconditional Logistic regression analysis. Results Single factor analysis showed that the factors related with the treatment outcome included age,sex,relevant clinical symptoms,combining other kinds of TB,delaying to visit doctors,intaking medicines before the treatment,cavity,non-supervised treatment during the whole treatment course,sputum positive after the treatment for 2 month and treatment without streptomycin for new smear-positive patients.Unconditional Logistic Regression analysis indicated that favorable factors influencing treatment outcome of pulmonary TB patients included fatigue and sputum positive result at the initiation of treatment, while the unfavorable factors influencing treatment outcome of pulmonary TB patients included symptoms and signs in the beginning of the treatment such as fever,cavity in the lung, non-supervised treatment during the whole treatment course and thenon-compliance which resulted in sputum positive after 2,3,5 months of treatment. Conclusion It is of great significance for improving TB patients’ prognosis by reducing patients’ delay to visit doctor through health education, increasing the directly supervised treatment during the whole treatment course to increase patients compliance of correct medication.

Key words: Pulmonary tuberculosis, Treatment, Factor analysis