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中国防痨杂志 ›› 2003, Vol. 25 ›› Issue (6): 360-362.

• 论著 • 上一篇    下一篇

不同全间歇短化方案治疗初治涂阳肺结核疗效的研究

李俊娟1;张联英1;张会民1;许海军1;曹继平2;刘金池3;侯烨4;刘立军3;   

  1. 1.河北省结核病预防中心 石家庄 050041; 2.河北省疾病预防控制中心 石家庄 050021; 3.沧州市卫生防疫站 沧州 061000; 4.保定市卫生防疫站 保定 071000;
  • 出版日期:2003-06-10 发布日期:2003-11-03

Study on the effect for initial smear positive pulmon ary tuberculosis cases treated with three short course(6 months)intermittent ch emotherapy regimens

LI Jun-juan,ZHANG Lian-ying,ZHANG Hui-min,et al.   

  1. HeBei research Institute for TB control,Shijiazhuang 050041
  • Online:2003-06-10 Published:2003-11-03

摘要: 目的 用2H2R2Z2S2(E2)/4H2R2和2H3R3Z3S3(E3)/4H2R2方案治疗初治涂阳肺结核,并与世行项目方案作对照,以探索最佳化疗方案。方法 随机抽取20个县(市)作为研究现场。将初治涂阳病人随机分为Ⅰ、Ⅱ、Ⅲ组且分别用不同的化疗方案,全程督导管理,观察痰菌阴转率和细菌学复发率。结果 3组6月末痰菌阴转率分别为95.96%、97.98%、97.37%,无统计学差异(P>0.05)。Ⅰ组副反应发生率与Ⅱ、Ⅲ组之间有统计学差异(P<0.05),但Ⅱ、Ⅲ组之间无统计学差异(P>0.05);复发率分别为4.86%、3.70%、2.76%,无统计学差异(P>0.05)。总疗程服药情况为Ⅰ、Ⅱ组病人较Ⅲ组服药次数明显减少。结论 研究方案与世行项目方案具有相似的化疗效果,Ⅰ组副反应发生率相对较低,其他2组之间无差异。研究组病人所需医药服务费用明显降低。

关键词: 结核, 肺/药物疗法

Abstract: Objective In order to find a good regimen to tre at tuberculosis patient,the study was carried out to treat initial smear positive TB cases with 2H2R2Z2S2(E2)/4H2R2,2H3R3Z3S3(E3)/4H2R2,compairedwith the result that TB cases treated with the regimen in TB contro l program in our country. Methods Twenty TB dispansaries were randomly selected as the st udy fields. Initial smear positive TB cases were chosen as study subjects and were divided into three groups(groupⅠ, groupⅡand group Ⅲ) randomly and were treated with different kinds of short course intermittent regimens of chemothera py.Results The smear negative conversion rates of the three g roups at the end of the sixth month during the treatment courses were 95.96%, 97 .98%, 97.37% respectively. There were not significant differences among them (P>0.05). Side effect rates of three groups after treatment were 22.73%, 33.88% and 40.00% respectively. The re were significant defferents between groupⅠand other two groups(P<0.01).B ut there was no significant difference between groupⅡ and group Ⅲ(P>0.05). The relapse rates of the three groups were 4.86%, 3.70% and 2.76% respectively and there were no significant differences among them(P>0.05). Average times of each cases of three groups ta king drugs in full treatment courses were 60, 70.48 and 90 times respectively. Conclusion The two experimental chemotherapy regimens have got almost the same Results with control group. The side effect rate of cases in group Ⅰ was less than th at in other two groups. The costs of the TB patients were reduced in the experim ent groups.

Key words: Tuberculosis, pulmonary/chemotherapy