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中国防痨杂志 ›› 2011, Vol. 33 ›› Issue (1): 61-65.

• 论著 • 上一篇    下一篇

弥漫性泛细支气管炎误诊为肺结核11例临床及误诊原因分析

吕康言 刘浩山 刘桑 磨月容   

  1. 广西龙潭医院 柳州 545005
  • 收稿日期:2009-07-22 出版日期:2011-01-20 发布日期:2012-01-19
  • 通信作者: 吕康言 E-mail:gxltyy1962@sina.com

Analysis of clinical and misdiagnosis of 11 cases of diffuse panbronchiolitis has been misdiagnosed as tuberculosis

Lv Kangyan; Liu Haoshan; Liu Sang; Mo Yuerong   

  1. Guangxi Longtan Hospital, Liuzhou 545005, China
  • Received:2009-07-22 Online:2011-01-20 Published:2012-01-19

摘要: 目的 通过分析弥漫性泛细支气管炎(diffuse panbronchiolitis,DPB)的临床特点及误诊为肺结核的原因,提高对两种疾病的鉴别诊断能力。方法 对11例误诊为肺结核的DPB临床特点及误诊原因进行回顾性分析。结果 11例患者主要症状为长期咳嗽、咳痰及气促,均合并有慢性副鼻窦炎,胸部影像表现主要为两肺弥漫性散在分布的颗粒样结节状或粟粒状阴影,肺功能检查结果为阻塞性通气功能障碍及低氧血症,3例血清冷凝集试验(CHA)效价增高(1:64以上),11例均被误诊为血行播散性肺结核,抗结核药物治疗无效而大环内酯类抗生素治疗病情好转明显。结论 误诊原因主要是对DPB缺乏认识,以及DPB与肺结核在临床表现与胸部X线影像表现相似。对诊断为血行播散性肺结核患者经抗结核治疗效果不佳且痰抗酸杆菌阴性时,结合临床表现应考虑到DPB。

关键词: 细支气管炎, 结核, 肺, 误诊

Abstract: Objective Through the analysis of diffuse panbronchiolitis(diffuse panbronchiolitis,DPB) the clinical characteristics and the reasons for misdiagnosed as pulmonary tuberculosis,Sharpening differential diagnosis ability which gets sick to two kind of illness.Methods Retrospective analysis of 11 cases misdiagnosed as tuberculosis in the clinical characteristics of DPB and the reason of misdiagnosis. Results  The main symptoms of patients with 11 cases of chronic cough, sputum and shortness of breath, the majority of the combined chronic sinusitis, chest imaging of pulmones diffuse mainly scattered in the granular nodular or miliary shadow of the results of pulmonary function tests obstructive ventilatory dysfunction and hypoxemia, 3 cases of serum cold agglutinin test (CHA) titer increased (more than 1:64), 11 cases were misdiagnosed as type disseminated tuberculosis, anti-TB drug treatment is invalid and macrocyclic esters of antibiotics in the treatment of patients improved significantly. Conclusion  The main causes of misdiagnosis is lack of awareness of DPB, and DPB is similar to tuberculosis in clinical performance and the performance of chest X-ray image. For blood in the diagnosis of disseminated tuberculosis by the anti-tuberculosis treatment of patients with poor results and negative sputum acid-fast bacilli, the combination of clinical performance should take into account the DPB.

Key words: bronchiolitis obliterans, tuberculosis, pulmonary, diagnostic errors