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中国防痨杂志 ›› 2022, Vol. 44 ›› Issue (7): 727-731.doi: 10.19982/j.issn.1000-6621.20220133

• 综述 • 上一篇    下一篇

中药治疗耐多药结核病的研究进展

杨驰1, 王振伟2, 沙巍1()   

  1. 1同济大学附属上海市肺科医院结核病临床研究中心上海市结核病(肺)重点实验室,上海 200433
    2上海中医药大学附属岳阳中西医结合医院呼吸科,上海 200080
  • 收稿日期:2022-04-15 出版日期:2022-07-10 发布日期:2022-07-06
  • 通信作者: 沙巍 E-mail:shfksw@126.com
  • 基金资助:
    上海市感染性疾病(结核病)临床医学研究中心(19MC1910800);上海市医学领军人才项目(2019KJ13);上海市临床重点专科(shslczdzk03001)

Advances in research on treatments of multidrug-resistant tuberculosis with Chinese traditional medicine

YANG Chi1, WANG Zhen-wei2, SHA Wei1()   

  1. 1The Center of Clinic and Research Center of Tuberculosis, Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
    2Department of Respiratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200080, China
  • Received:2022-04-15 Online:2022-07-10 Published:2022-07-06
  • Contact: SHA Wei E-mail:shfksw@126.com
  • Supported by:
    Shanghai Clinical Research Center for Infectious Diseases(19MC1910800);Program for Outstanding Medical Academic Leader(2019KJ13);Shanghai Key Clinical Specialty Construction Project(shslczdzk03001)

摘要:

耐多药结核病是由耐多药结核分枝杆菌原发感染或抗结核药物用药不当产生继发耐药所致,已成为世界卫生组织2035年终止结核病流行策略的一大阻碍,目前治愈率不理想。因此,迫切需要开发新的抗结核药物或治疗方法。中医药在减轻结核病症状、联合西药治疗耐多药结核病,以及提高患者针对结核分枝杆菌的免疫水平方面已有很多研究。作者对中药抗结核治疗的体外及人体试验研究进展进行综述,以期为临床医生提供更多的有关中西医结合治疗结核病的思路和策略。

关键词: 结核, 抗多种药物性, 医学, 中国传统, 治疗学

Abstract:

Multidrug-resistant tuberculosis (MDR-TB) is caused by the primary infection of drug-resistant Mycobacterium tuberculosis (MTB) or improper tuberculosis treatment, which has become a major obstacle to end tuberculosis before 2035. Due to its poor cure rate, there is an urgent need to develop new anti-tuberculosis drugs or treatment strategy. Chinese traditional medicine could alleviate the patients’ symptoms, reduce the toxicity and enhance effect when combined with anti-tuberculosis therapy, as well as improve patients’ immunity. The authors review the progress of Chinese traditional medicine of anti-tuberculosis treatments, which may provide more thoughts and strategies for clinicians.

Key words: Tuberculosis, multidrug-resistant, Medicine, Chinese traditional, Therapeutics