衔接分子胱天蛋白酶募集域蛋白9与抗结核免疫的相关性

中国防痨杂志 ›› 2013, Vol. 35 ›› Issue (3): 204-206.

衔接分子胱天蛋白酶募集域蛋白9与抗结核免疫的相关性

孙蕾郑锦辉王毳费思平赵卓

110005 沈阳，辽宁省疾病预防控制中心（孙蕾、王毳、赵卓）；沈阳军区二O二医院老干部科（郑锦辉）；辽宁省卫生厅应急项目办公室（费思平）

收稿日期:2012-08-21 出版日期:2013-03-10 发布日期:2013-03-14
通信作者: 孙蕾 E-mail:offies@163.com

The relationship between the adaptor molecule caspase recruitment domain-containing protein 9 and anti-tuberculosis immunity

SUN Lei, ZHENG Jin-hui，WANG Cui, FEI Si-ping，ZHAO Zhuo

Liaoning Provincial Center for Disease Control and Prevention,Shenyang 110005，China

Received:2012-08-21 Online:2013-03-10 Published:2013-03-14
Contact: SUN Lei E-mail:offies@163.com

摘要/Abstract

摘要： 结核病是一种慢性传染病，全球每年有170万例患者死于结核病。我国结核病患者例数居世界第二位，也是耐药结核病流行严重的国家之一，因结核病死亡的人数超过其他传染病死亡人数的总和。因此，研制有效的抗结核药物和新型疫苗迫在眉睫。这需要对宿主与Mtb相互作用机制、抗原提呈细胞（antigen presenting cell, APC）内部信号传导机制及其关键分子进行深入理解。宿主感染Mtb后，通过模式识别受体（pattern recognition receptors, PRRs）识别Mtb表面病原体相关分子模式（pathogen-associated molecular patterns, PAMPs），并将信号传递给衔接分子，后者启动下游的信号级联反应，诱导固有免疫细胞合成细胞因子，活化宿主免疫机制。本综述对一种重要的衔接分子胱天蛋白酶募集域蛋白9(caspase recruitment domain-containing protein 9,CARD9)及其与抗结核免疫的相关性进行简要阐述，为结核病的治疗和疫苗的研制提供参考。

关键词: 结核/免疫学, CARD信号接头蛋白质类

Abstract: Tuberculosis(TB) is a chronic infectious disease, globally 1.7 million people die from TB annually.The number of TB patients in China ranks the second in the world. China is one of the countries with high prevalence of multi-drug resistance TB (MDR-TB). The number of TB deaths exceeds the sum of the number of deaths caused by other infectious diseases. Therefore, the development of effective anti-TB drugs and new vaccines is imminent. This requires the in-depth understanding of the interaction mechanism between the host and Mtb, and the internal signaling mechanisms and the key molecules of antigen presenting cell(APC). When the pathogen-associated molecular patterns(PAMPs) of Mtb is recognized by pattern recognition receptors (PRRs), the signal is transmitted to the adaptor molecule which starts the downstream signaling cascade reaction, induces innate immune cells to synthesize cytokines, and activates the host immune mechanisms. This review briefly elaborated the correlation between caspase recruitment domain-containing protein 9 (CARD9) and anti-TB immunity, and provided a reference for the TB treatment and the development of vaccine.

Key words: Tuberculosis/immunology, CARD signaling adaptor proteins

孙蕾郑锦辉王毳费思平赵卓. 衔接分子胱天蛋白酶募集域蛋白9与抗结核免疫的相关性[J]. 中国防痨杂志, 2013, 35(3): 204-206.

SUN Lei, ZHENG Jin-hui，WANG Cui, FEI Si-ping，ZHAO Zhuo. The relationship between the adaptor molecule caspase recruitment domain-containing protein 9 and anti-tuberculosis immunity[J]. Chinese Journal of Antituberculosis, 2013, 35(3): 204-206.

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