[1]Capecchi MR. The new mouse genetics: altering the genome by gene targeting. Trends Genet, 1989, 5(3):70-76.[2]Capecchi MR. Altering the genome by homologous recombination. Science, 1989, 244(4910):1288-1292. [3]Gu H, Marth JD, Orban PC, et al. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science, 1994, 265(5168):103-106.[4]Gama Sosa MA, De Gasperi R, Elder GA. Animal transgenesis: an overview. Brain Struct Funct, 2010, 214(2/3):91-109.[5]Chaible LM, Corat MA, Abdelhay E, et al. Genetically modified animals for use in research and biotechnology. Genet Mol Res, 2010, 9(3):1469-1482.[6]Hasty P, Ramirez-Solis R, Krumlauf R, et al. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature, 1991, 350(6315):243-246. [7]Askew GR, Doetschman T, Lingrel JB. Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy. Mol Cell Biol, 1993, 13(7): 4115-4124. [8]Sedivy JM, Dutriaux A.Gene targeting and somatic cell genetics:a rebirth or coming of age? Trends Genet, 1999, 15(3):88-90. [9]Zhang X, Wu Y, Luo F, et al. Construction of targeting vector for expressing human GDNF in Cattle mammary gland. Appl Biochem Biotechnol, 2009, 159(3):718-727.[10]Miller JL, Velmurugan K, Cowan MJ, et al. The Type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-alpha-mediated host cell apoptosis. PLoS Pathog, 2010, 6(4):e1000864.[11]Hu Y, Coates AR. Acute and persistent Mycobacterium tuberculosis infections depend on the thiol peroxidase TpX. PLoS One, 2009, 4(4):e5150.[12]吴芳,张万江,曹旭东,等. 卡介苗ERP基因置换型打靶载体的构建. 农垦医学, 2005, (5):332-334.[13]Kondratieva TK, Rubakova EI, Linge IA, et al. B cells delay neutrophil migration towards the site of stimulus: tardiness critical for effective bacillus Calmette-Guérin vaccination against tuberculosis infection in mice. J Immunol, 2010, 184(3):1227-1234.[14]Briken V, Porcelli SA, Besra GS, et al. Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response. Mol Microbiol, 2004, 53(2):391-403. [15]Zhang N, Torrelles JB, McNeil MR, et al. The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N-terminal recognition region and a Cterminal synthetic region. Mol Microbiol, 2003, 50(1):69-76.[16]李娅莎,鲍朗,李岩,等. 卡介苗阿拉伯糖苷转移酶embC基因敲除株的构建和初步鉴定. 中国微生态学杂志, 2009, 21(5):440-442.[17]Braunstein M, Espinosa BJ, Chan J. SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis. Mol Microbiol, 2003, 48(2):453-464.[18]Lewis KN, Liao R, Guinn KM, et al. Deletion of RD1 from Mycobacterium tuberculosis mimics bacille Calmette-Guérin attenuation. J Infect Dis, 2003,187:117-123. |