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中国防痨杂志 ›› 2010, Vol. 32 ›› Issue (12): 791-794.

• 病案报告 • 上一篇    下一篇

HIV/AIDS患者结核感染预防性治疗效果评价研究

殷继国; 何卫华; 练祖银; 刘焰东; 周沛林; 萧爱清; 刘凤仁;   

  1. 1.湖北省随州市疾病预防控制中心; 2.湖北省疾病预防控制中心结核病防治所; 3.华中科技大学同济医学院公共卫生学院;
  • 出版日期:2010-12-15 发布日期:2011-08-23
  • 基金资助:

    湖北省科学技术攻关项目(2006AA301C50)

Efficacy of prophylactic treatment for tuberculosis infection in patients with HIV/AIDS

Yin Jiguo1; He Weihua; Lian Zuyin; Liu Yandong; Zhou Peilin; Xiao Aiqing; Liu Fengren.   

  1. 1.Center for disease control and prevention of Suizhou city; Hubei province; Suizhou 441300; China; 2.Center for TB control and prevention; Hubei center for Disease control and prevention; Wuhan 430079; 3.Department of public health; Tongji Medical university; Huazhong colledge of science and techaology; Wuhan 430030;
  • Online:2010-12-15 Published:2011-08-23

摘要: 目的了解异烟肼预防性治疗对HIV/AIDS患者结核感染的预防性效果。方法对湖北省随州市2006年符合预防性治疗标准的HIV/AIDS患者进行9个月的异烟肼预防性治疗,随访观察其治疗结果并与2005年的相关资料进行对比分析。结果对HIV总人群来说,异烟肼预防性治疗对预防结核的发生(P=0.18)及病例的死亡无显著影响(P=0.06),但对PPD(+)的HIV患者的死亡(P=0.03)与结核发病有明显的保护作用(P=0.00),且不良反应轻微。结论 PPD(+)的HIV患者实施9个月的异烟肼预防性治疗是切实可行的,具有明显的保护效果。

关键词: 获得性免疫缺陷综合征, 结核/预防和控制, 治疗结果

Abstract: Objective To investigate the efficacy of prophylactic treatment with Isoniazid for tuberculosis infection in patients with HIV/AIDS.Methods Participants who were enrolled according to the prophylactic treatment standard in Suizhou City of Hubei province were treated with Isoniazid for nine months in 2006,and were followed-up for treatment outcomes.The data were compared with that of 2005.Results For all HIV-infected patients,9 month Isoniazid Treatment had no protection regarding to tuberculosis morbidity(P...

Key words: acquired immunodeficiency syndrome, tuberculosis/prevention and control, treatment outcome

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