复治病人中影响耐药产生因素的分析

中国防痨杂志 ›› 2006, Vol. 28 ›› Issue (1): 28-30.

复治病人中影响耐药产生因素的分析

徐旭卿¹；陈坤¹；李群²；

1浙江大学医学院杭州 310031；2浙江省疾病预防控制中心杭州 310009；

出版日期:2006-01-10 发布日期:2006-11-03

The analysis of causes that result in re-treatment of drug-resistant tuberculosis in Zhejiang

Xu Xuqing,Chen Kun,Li Qun.

1.Zhejiang University School of Medicine,Hangzhou 310031,China

Online:2006-01-10 Published:2006-11-03

摘要/Abstract

摘要： 目的研究探讨复治病人耐药与敏感原因的差别,分析造成获得性耐药的危险因素。方法选择15个“WHO结核病耐药监测”县(市)复治耐药与非耐药病人为调查对象,采用流行病学问卷调查法进行相关项目调查。结果耐药与敏感复治肺结核病人在初治诊断治疗单位、初治治疗管理方式构成上无差别;在复治年限、复治原因构成上有差别。复治病人单因素分析中“无管理自服药”、“不规则治疗或中断治疗”是造成复治耐药的主要因素。结论长期复治、化疗管理不善造成的“不规则治疗或中断治疗”都是获得性耐药的危险因素。

关键词: 结核,肺/预防和控制, 结核,抗药性, 浙江省

Abstract: Objective To study the different causes that result in re-treatment of drug-resistant and drug-sensitive TB in Zhejiang in order to find the risk factors that result in acquired drug-resistant TB.Method 15 counties were randomly selected from 30 surveillance counties of a global drug-resistance surveillance of TB project of WHO.Drugresistance and drug-sensitive TB cases were intaken continuously in each counties.The method of epidemiological survey with questionnaire was used.Results Between drug-resistance and drug-sensitive TB,there was no significant difference in the proportion of initial treatment unit and management mode.But there was difference in the proportion of re-treatment cluration and re-treatment causes.The main reasons of re-treatment were that the patients who treated in general hospital,or did not manage by health workers or irregularly treated.Conclusion The risk factors that result in acquired drug-resistant TB were long-term re-treatment and irregularly treated.

Key words: Pulmonary tuberculosis/prevention and control, Tuberculosis,Drug-resistant, Zhejiang

徐旭卿,陈坤,李群,. 复治病人中影响耐药产生因素的分析[J]. 中国防痨杂志, 2006, 28(1): 28-30.

Xu Xuqing,Chen Kun,Li Qun.. The analysis of causes that result in re-treatment of drug-resistant tuberculosis in Zhejiang[J]. Chinese Journal of Antituberculosis, 2006, 28(1): 28-30.

[1]	陈松华,刘北斗,王晓萌,陈苘,. 浙江省结核病控制人力资源现状分析[J]. 中国防痨杂志, 2006, 28(6): 345-347.
[2]	赵晓春,虞筱华,. 浙江省温州市流动人口涂阳肺结核项目管理效果分析[J]. 中国防痨杂志, 2005, 27(6): 396-398.
[3]	刘北斗,李群,徐旭卿,缪梓萍,陈松华,杨石波,郑锦雷,. 浙江省结核病特定知识知晓率调查结果分析[J]. 中国防痨杂志, 2005, 27(6): 385-388.
[4]	王甦民,王雪静,赵新平,钟球,李群,武桂英,龚幼龙,游永红,端木宏谨,. 浙江、广东省耐药监测项目中耐药肺结核治疗现况研究[J]. 中国防痨杂志, 2005, 27(6): 370-373.
[5]	杨石波,李群,缪梓萍,. 浙江省CIDA/WHO中国结核病控制项目实施效果分析[J]. 中国防痨杂志, 2005, 27(5): 293-295.
[6]	李群,杨石波,徐旭卿,何铁牛,刘北斗,. 浙江省结核病控制项目实施效益分析评价[J]. 中国防痨杂志, 2005, 27(4): 251-254.
[7]	李群,杨石波,徐旭卿,陈松华,. 浙江省肺结核病人发现模式和效果分析评价[J]. 中国防痨杂志, 2004, 26(4): 195-198.
[8]	杨石波,李群,缪梓萍,. 浙江省2001—2002年外来人口中肺结核病监测结果分析[J]. 中国防痨杂志, 2004, 26(3): 170-172.