SARS患者血清干扰素-2α和肿瘤坏死因子水平检测

中国防痨杂志 ›› 2005, Vol. 27 ›› Issue (2): 109-110.

SARS患者血清干扰素-2α和肿瘤坏死因子水平检测

叶一秀；王巍；王安生；王仲元；李洪敏；林明贵；陈红兵；王金河；

解放军第309医院北京 100091；

出版日期:2005-02-10 发布日期:2005-11-03

Detection of interferon-2α and tumor necrosis factor in patiens with severe acute respiretory syndrome

Ye Yixiu,Wang Wei, Wang Ansheng,et al.

The 309th Hospital of PLA,Beijing 100091, China

Online:2005-02-10 Published:2005-11-03

摘要/Abstract

摘要： 目的　观察SARS患者血清干扰素-2α(IFN-2α)和血清肿瘤坏死因子(TNF)含量变化。方法用放射免疫法检测了66例SARS患者血清IFN-2α和TNF含量,并与正常对照组作了比较。结果 SARS组进展期患者IFN-2α含量明显高于对照组,重型SARS患者血清IFN-2α含量高低不一。SARS组进展期患者TNF含量明显高于对照组,重型SARS患者血清TNF含量明显高于普通型。结论患者血清IFN-2α和TNF含量变化提示细胞免疫参与了机体的免疫反应,重症SARS患者IFN-2α和TNF含量变化反映了患者的免疫机能状况差异。

关键词: 严重急性呼吸综合征, 血清, 干扰素, 肿瘤坏死因子

Abstract: Objective To observe the levels of serum Interferon-2α(IFN-2α) and Tumor necrosis factor (TNF) in patients with Severe acute respiretory syndrome(SARS). Methods The serum IFN-2αand TNF in 66 patients with SARS were analyzed by RIA, and compared with controls. Results The levels of serum IFN-2αand TNF in patients with active period of SARS were significantly higher than those in controls. The levels of serum IFN-2αin severe type of patients were rise or fall, and TNF in severe type of patients were higher than general type. Conclusion The change of levels of serum IFN-2αand TNF suggested that cellular immunity was involved in immunoreaction. The change of IFN-2αand TNF in severe type of patients with SARS reflected the difference of immunoreaction in patients.

Key words: SARS, Interferon-2α, Tumor necrosis factor

叶一秀,王巍,王安生,王仲元,李洪敏,林明贵,陈红兵,王金河,. SARS患者血清干扰素-2α和肿瘤坏死因子水平检测[J]. 中国防痨杂志, 2005, 27(2): 109-110.

Ye Yixiu,Wang Wei, Wang Ansheng,et al.. Detection of interferon-2α and tumor necrosis factor in patiens with severe acute respiretory syndrome[J]. Chinese Journal of Antituberculosis, 2005, 27(2): 109-110.

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