西利宾胺预防抗结核药物肝损害的临床观察

中国防痨杂志 ›› 2005, Vol. 27 ›› Issue (2): 104-106.

西利宾胺预防抗结核药物肝损害的临床观察

董安国；许金云；崔冬梅；

山东省枣庄市王开结核病防治院枣庄 277500；

出版日期:2005-02-10 发布日期:2005-11-03

The clinical study on preventing medicamentous liver lesion induced by antituberculosis drugs of silybin meglumine tablebs

Dong Anguo,Xu Jinyun,Cui Dongmei.

Wangkai Tuberculosis Hospital Zaozhuang,Zaozhuang 277500, China

Online:2005-02-10 Published:2005-11-03

摘要/Abstract

摘要： 目的　探讨西利宾胺对初治菌阳肺结核患者抗结核药物肝损害的预防效果。方法 242例初治菌阳肺结核分为观察组和对照组,均应用“2HRZS(E)/4HR”方案抗结核化疗,观察组加用西利宾胺,对照组加肝泰乐。结果观察组药物性肝损害发生率为6.6%;中断抗结核化疗为41%;调整化疗方案为16%;与对照组的19.2%、14.2%、9.2%比较,均有显著性差异(P<0.01)。结论西利宾胺可显著降低初治菌阳肺结核患者抗结核药物肝损害的发生率,减少因抗结核药所致肝损害而造成的不规则化疗。

关键词: 结核,肺/药物疗法, 肝损害,西利宾胺

Abstract: Objective To study the preventive efficacy of Silybin meglumine tablets on medicamentous liver lesion by antituberculosis drugs. Methods 242 sputum positive initial treated pulmonary tuberculosis were divided into two groups, study group and control group randomly,which were both treated by chemotherapy regimen of 2HRZS(E)/4HR.The study group also took TSM. Results In the study group the morbidity of medicamentous liver lesion was 6.6%,the incidence rate of interrupting treatment was 4.1%,1.6%of cases adjusted the antituberculosis regemen. And the control group was 19.2%,14.2% and 19.2% respectively.There were very significant difference between the two groups(P<0.01).Conclusion Silybin Meglumine tablets can obviously decrease the incidence rate of liver damage of sputum positive initial treated patients induced by antituberculosis drugs and decrease or prevent the irregular chemotherapy that Results from the liver damage caused by antituberculosis drugs.

Key words: pulmonary tuberculosis/drug therapy, liver lesion, Silybili Meglumine tablets

董安国,许金云,崔冬梅,. 西利宾胺预防抗结核药物肝损害的临床观察[J]. 中国防痨杂志, 2005, 27(2): 104-106.

Dong Anguo,Xu Jinyun,Cui Dongmei.. The clinical study on preventing medicamentous liver lesion induced by antituberculosis drugs of silybin meglumine tablebs[J]. Chinese Journal of Antituberculosis, 2005, 27(2): 104-106.