警惕抗结核药物引起血液系统的异常

中国防痨杂志 ›› 2004, Vol. 26 ›› Issue (6): 338-340.

警惕抗结核药物引起血液系统的异常

朱敏¹；刘亚东²；赵茜¹；俞洁¹；

1.浙江省中西医结合医院结核病治疗中心杭州 310003；2.浙江省杭州市第二医院杭州 310003；

出版日期:2004-06-10 发布日期:2004-11-03

On guard against antituberculosis drugs cause the abnormality of hematological system

Zhu Min,Liu Yadong,Zhao Qian,et al

Zhejiang Combining Traditional Chinese Medicine and West Medicine Hospital,Hangzhou 310003

Online:2004-06-10 Published:2004-11-03

摘要/Abstract

摘要： 目的　观察抗结核药物对血液系统的影响。方法回顾性分析1996年1月—2004年1月抗结核治疗中发生血液系统异常改变的115例的临床资料。结果 4812例结核病人抗结核治疗中发生血液系统异常改变115例(2.4%),以白细胞减少最常见(44.4%),其次是全血细胞减少(22.6%)及白细胞合并血小板减少(10.4%)。罕见有再生障碍性贫血、溶血性贫血、继发性骨髓纤维化。结论几乎所有抗结核药物均可引起血液系统异常,以利福霉素类引起最常见,其次为吡嗪酰胺、异烟肼。既可引起血液系统中的一种有形成分改变,又可引起全血系统的异常,严重者引起死亡,应引起警惕。

关键词: 抗结核药物, 血液系统, 异常

Abstract: Objective To evaluate the effects of antitubercu lo sis drugs in hematological system.Methods The clinical data of 115 pulmonary patients with the abnormality in hematological system from Jan.199 6 to Jun.2004,were reviewed retrospectively.Results In 4812 tuberculosis cases,the abnormality in hematol ogical system were 115 (2.4%),aleucocytosis were most common existed (44.4%),th e second were pancytopenia (22.6%) and thrombocytopenia with hypolekocytosis (10.4%).aplastic anemia,HA and SMF were seldom seen.Conclusion Almost all the antituberculosis drugs can cause abno rmality of hematological system.Rifomycins were most common next were aldinamide and isoniazide.It can cause a formed elements to change in blood.A nd cause the abnormality of whole blood,and death in serious patients cause.So it should be on guard against.

Key words: Antituberculosis drugs, Hematological system, Abnormal ity

朱敏,刘亚东,赵茜,俞洁,. 警惕抗结核药物引起血液系统的异常[J]. 中国防痨杂志, 2004, 26(6): 338-340.

Zhu Min,Liu Yadong,Zhao Qian,et al. On guard against antituberculosis drugs cause the abnormality of hematological system[J]. Chinese Journal of Antituberculosis, 2004, 26(6): 338-340.

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