白细胞介素-6和转铁蛋白检测在胸腔积液诊断中的价值

中国防痨杂志 ›› 2004, Vol. 26 ›› Issue (3): 148-150.

白细胞介素-6和转铁蛋白检测在胸腔积液诊断中的价值

胡云良¹；陈新宇¹；林洁¹；李玉萍²；李杰³；黄小芳²；

1.温州医学院附属第二医院温州 325027；2.温州医学院附属第一医院温州 325003；3.浙江省台州出入境检验检疫局台州 318000；

出版日期:2004-03-10 发布日期:2004-11-03

The differential diagnosis value of Interleukin-6 and Transferrin in pleural effusion

Hu Yunliang,Chen Xinyu,Lin Jie,et al.

Department of Clinical Laboratory, the 2nd Hospital Affiliated to Wenzhou Medical College,Wenzhou 325027

Online:2004-03-10 Published:2004-11-03

摘要/Abstract

摘要： 目的　探讨胸腔积液患者胸水中IL-6和TRF两项指标对胸腔积液性质鉴别诊断的实用价值。方法将 93例不同病因的胸腔积液患者分成漏出液组、结核性渗出液组和恶性渗出液组,平行检测患者胸腔积液中IL-6和TRF的水平。通过受试者工作特征曲线 (ROC)评价两项指标对胸腔积液性质的诊断价值。结果 IL-6在三组胸腔积液中差异均有意义 (均P＜0.05)。以结核性渗出液组中最高,漏出液组最低。渗出液中TRF比漏出液中TRF高 (P＜0.05),分别以 95pg/ml、70mg dl作为IL 6、TRF诊断漏出液与渗出液的临界值,诊断渗出液的灵敏度为 95.2%、85.7%特异度为93.3%、70%。结论 IL-6具有较高的灵敏度与特异度。胸腔积液IL-6、TRF检测对鉴别胸腔积液性质有一定的实用价值。

关键词: 转铁蛋白, 白细胞介素-6, 胸腔积液, 受试者工作特征曲线(ROC), 结核/诊断

Abstract: Objective To determine the differential diagnosis value of the levels of Interleukin-6 (IL-6)、Transferrin (TRF) in pleural effusion in patients with pleural effusion.Methods Ninety-three cases with differential diagnostic pleural effusion were divided into transudatory pleural,tuberculous exudative and malignant exudative groups.IL-6、TRF were simultaneously determined in three groups,and the value of two indices was evaluated by receiver operating characteristic curve (ROC).Results The levels of IL-6 were significant difference among three groups.The level of IL-6 in tuberculous exudative group was the highest,and that in transudatory pleural group was the lowest.The level of TRF in exudative pleural group was higher than that in transudatory pleural group (P＜0.01);Regarding 95pg/ml as the cut off value of IL-6 and 70mg/dl as that of TRF to distinguish exudative pleural effusion from transudatory pleural effusion,the sensitivities in diagnosis exudative pleural effusion was 95.2%,85.7% respectively and the specialities was 93.3%,70% respectively.Conclusion The speciality and sensitivity of IL-6 were higher.There are diagnostic values in IL-6、TRF for identifying the property of pleural effusion.

Key words: Transferrin, Interleukin-6, Pleural effusion, Receiver operating charcteristic curve (ROC), Tuberculosis/diagnosis

胡云良,陈新宇,林洁,李玉萍,李杰,黄小芳,. 白细胞介素-6和转铁蛋白检测在胸腔积液诊断中的价值[J]. 中国防痨杂志, 2004, 26(3): 148-150.

Hu Yunliang,Chen Xinyu,Lin Jie,et al.. The differential diagnosis value of Interleukin-6 and Transferrin in pleural effusion[J]. Chinese Journal of Antituberculosis, 2004, 26(3): 148-150.

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