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中国防痨杂志 ›› 2002, Vol. 24 ›› Issue (6): 340-342.

• 论著 • 上一篇    下一篇

现代结核病控制措施下结核病传染参数的研究

何广学;   

  1. 中国疾病预防控制中心结核病预防控制中心 北京 100050;
  • 出版日期:2002-06-10 发布日期:2002-11-03

TB transmission parameter under modern tuberculosis control strategy

HE Guang xue.   

  1. National Center for Tuberculosis Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100050
  • Online:2002-06-10 Published:2002-11-03

摘要: 目的 探索现代结核病控制措施 (DOTS)下的结核病传染参数。方法 北京市顺义区自1978年开始对传染性肺结核病人采取现代结核病控制措施 (DOTS)。1988年7月全县开始停止新生儿卡介苗接种,并对儿童采取了一系列保护性预防措施。1995年按照WHO和IUATLD推荐的国际标准结核菌素试验技术并采用国际标准PPD,对1988~1989年停止卡介苗接种的12849名6~7岁小学一年级儿童进行PPD皮内试验。根据PPD试验反应硬结分布情况,以PPD反应硬结横径≥10mm为结核自然感染标准,然后,根据公式计算年结核感染率和传染参数。结果 顺义区结核自然感染率为1.35%,推算年结核感染率为0.21%。与此同时,痰涂片阳性肺结核病人的年患病率为21.7/10万~39.1/10万,由此计算传染参数约为6。结论 北京市顺义区的结核病传染参数约为6,也就是1名传染源每年平均传染6名健康人,充分说明北京市顺义区所采取的现代结核病控制措施(DOTS)对控制结核病传染源、减少结核菌传播以及保护健康人群十分有效。

关键词: 结核,预防控制, 结核,传染参数, DOTS

Abstract: Objective To explore the tuberculosis transmission parameter under modern tuberculosis control strategy (DOTS).Methods Since 15 July 1988,the BCG vaccination for newborns in Shun Yi County of Beijing was discontinued, and a series of protective measures,mainly conducted DOTS,for children were taken at the same time.PPD tuberculin tests for the nonvaccinated 6~7 years children born in 1988~1989 of first grade of primary schools,done with international standard tuberculin (2 TU PPD Rt23+Tween 80),were conducted according to WHO/IUATLD procedures in 1995.The criterion for infection was an induration of 10mm or more according to the distribution of PPD test reaction.Results The prevalence of tuberculosis infection was 1.35%.The annual risk of TB infection (ARTI) was 0.21%. At meantime, the prevalence of smear positive pulmonary tuberculosis in Shun yi County were (21.7~39.1)/105 per year.So the TB transmission parameter was about 6.Conclusion The TB transmission parameter was 6 in Shun yi County of Beijing that means an infectious tuberculosis case can infect 6 persons averagely per year.This result indicated that the modern tuberculosis control strategy (DOTS) in Shun Yi County has highly effect on controlling sources of infection,reducing infection, protecting healthy population.

Key words: Tuberculosis/Prevention and control, Tuberculosis/Transmission parameter, DOTS