初治涂阳肺结核不固定化疗期全程间歇短化效果观察

中国防痨杂志 ›› 2002, Vol. 24 ›› Issue (4): 213-215.

初治涂阳肺结核不固定化疗期全程间歇短化效果观察

路丽¹；张联英¹；曹继平²；董军³；陈建丽³；贵永⁴；于德礼⁵；杜军花⁶；

1河北省结核病预防中心石家庄 050041；2河北省疾病预防控制中心石家庄 050021；3河北省唐山市结核病防治所；唐山 063000；4丰南市卫生防疫站丰南 063000；5玉田县卫生防疫站玉田 063000；6滦南县卫生防疫站滦南 063000；

出版日期:2002-04-10 发布日期:2002-11-03

The effect observation of initial smear-positive pulmonarytuberculosis cases treated with short-course intermittent unfixed-course chemotherapy regimen

LU Li¹, ZHANG Lian-ying, CAO Ji-ping, et al.

1.Hebei Province Tuberculosis Prevent Center, Shijiazhuang 050041

Online:2002-04-10 Published:2002-11-03

摘要/Abstract

摘要： 目的　观察不固定化疗期全程间歇短化方案治疗初治涂阳肺结核病人的近远期疗效及缩短疗程的可能性。方法选取440例初治涂阳肺结核病人,随机分为新方案组和原方案组。新方案组病人采用不固定化疗期全程间歇短化方案(2～3)H₃R₃Z₃S₃(E₃)/(2～6)H₃R₃,原方案组病人采用6个月疗程的全程间歇短化方案2H₃R₃Z₃S₃(E₃)/4H₃R₃。结果两组病人满疗程痰菌阴转率分别为98.6%和98.2%。随访一年复发率分别为1.5%和2.0%。以上两组结果比较无显著性差异(P>0.05)。新方案组平均疗程为4.8个月。比原方案组疗程缩短1.2个月。结论不固定化疗期全程间歇短化方案治疗初治涂阳肺结核病人,获得与固定化疗期方案相同的近远期疗效。不固定化疗期疗法可使6个月固定化疗期方案疗程缩短,减少服药次数,节省病人医药费用、使病人易于配合。但在日常工作中使用是否有问题有待观察。

关键词: 结核,肺/药物疗法, 不固定化疗期

Abstract: Objective To understand the therapeutic effect and chemotherapy course of intermittent unfixed course regimen with which the initial smear positive pulmonary tuberculosis cases were treated. Methods 440 cases of initial smear positive pulmonary TB cases were selected and divided randomly in the new regimen group and the old regimen group. The TB cases in the new regimen group were treated with the intermittent unfixed course chemotherapy regimen, (2～3)H ₃R₃Z₃S₃(E₃)/(2～6)H₃R₃. The ones in the old regimen group were treated with the 6 month intermittent chemotherapy regimen, 2H₃R₃Z₃S₃(E ₃)/4H₃R₃. Results The sputum conversion rates of the cases in two groups were 98.6% and 98.2% at the end of six months respectively. The relapse rates of one year were 1.5% and 2.0% respectively. There were not significant differences in all indexes between the two groups ( P >0.05). The average course of the new regimen group was 4.8 months. It is 1.2 months shorter than the olds. Conclusion The initial smear positive pulmonary TB cases that were treated with the intermittent unfixed course chemotherapy regimen had achieved the same effects as with the fixed one. The unfixed course method can shorten the course of the fixed course method. It posses the characteristics of less cost of patient’s and the patients are easy to cooperate with the doctor.

Key words: Tuberculosis,Pulmonary/chemotherapy, Unfixed course Regimen

路丽,张联英,曹继平,董军,陈建丽,贵永,于德礼,杜军花,. 初治涂阳肺结核不固定化疗期全程间歇短化效果观察[J]. 中国防痨杂志, 2002, 24(4): 213-215.

LU Li¹, ZHANG Lian-ying, CAO Ji-ping, et al.. The effect observation of initial smear-positive pulmonarytuberculosis cases treated with short-course intermittent unfixed-course chemotherapy regimen[J]. Chinese Journal of Antituberculosis, 2002, 24(4): 213-215.