抗结核药物预防煤尘肺并发肺结核的效果观察

中国防痨杂志 ›› 2000, Vol. 22 ›› Issue (4): 192-193.

抗结核药物预防煤尘肺并发肺结核的效果观察

刘素芹¹；任建军¹；杨怀¹；曲峰¹；胡念岭²；陈伟²；王纪祥³；陈广信³；

1.安徽淮北矿务局卫生防疫站 235000； 2.淮北矿务局职业病防治院 235000； 3.安徽省结核病防治所 230022；

出版日期:2000-04-10 发布日期:2000-04-10

The effect of reducing incidence of TB by prophylactic chemotherapy in patients with coal-pneumoconiasis

LIU Su-qin,REN Jian-jun,YANG Huai,et al.

Sanitation and Anti-epidemic Station of Huaibei Mineral Office,Anhui 235000

Online:2000-04-10 Published:2000-04-10

摘要/Abstract

摘要： 目的　了解煤尘肺病人预防性服用异烟肼、利福平以减少煤尘肺病人并发肺结核的情况。方法用双盲法将Ⅰ、Ⅱ期煤尘肺病人随机分为三组,分别服用异烟肼、利福平和安慰剂。结果通过5年观察显示服异烟肼和利福平两组煤尘肺病人合并肺结核者明显低于服用安慰剂组(P<0.01)。结论给予对煤尘肺患者实施预防性服用异烟肼、利福平可有效地减少肺结核的发生。

关键词: 结核,肺, 煤尘肺, 预防化疗

Abstract: Objective To observe the effect of reducing incidence of TB by prophylactic chemotherapy in cases with coal-pneumoconiasis.Methods 269 cases with stage Ⅰ,Ⅱ of coal-pneumoconiasis were devided to 3 groups and to take INH,RFP and placebo respectively for 3～6 months.Results Through after 5 years observation showed the incidence of TB was reduced signifficanly in the group A and group B (take INH or RFP) than The control group(P<0.01).Conclusion The prophylactic chemotherapy(INH,RFP) will reducing the incidence of TB in patients with coal-pneumoconiasis effectively.

Key words: Tuberculosis,pulmonary, Coal-pneumoconiasis, Prophylactic chemotherapy

刘素芹,任建军,杨怀,曲峰,胡念岭,陈伟,王纪祥,陈广信,. 抗结核药物预防煤尘肺并发肺结核的效果观察[J]. 中国防痨杂志, 2000, 22(4): 192-193.

LIU Su-qin,REN Jian-jun,YANG Huai,et al.. The effect of reducing incidence of TB by prophylactic chemotherapy in patients with coal-pneumoconiasis[J]. Chinese Journal of Antituberculosis, 2000, 22(4): 192-193.

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