北京市西城区新发肺结核病人起始耐药性监测

中国防痨杂志 ›› 1999, Vol. 21 ›› Issue (1): 17-19.

北京市西城区新发肺结核病人起始耐药性监测

沈秀萍；徐瑞兴；吕晶；

北京市第二医院

收稿日期:1998-05-25 修回日期:1998-08-27 出版日期:1999-01-10 发布日期:1999-01-10

Monitor of initial drug resistance in new cases of pulmonary tuberculosis in Xicheng district,Beijing

Shen Xiuping,Xu Ruixing,Lu Jing.

Beijing Secand Hospital,Beijing 100031

Received:1998-05-25 Revised:1998-08-27 Online:1999-01-10 Published:1999-01-10

摘要/Abstract

摘要： 目的报道1984～1995年北京市西城区新发肺结核病人起始耐药性的监测结果?方法全部新发肺结核病人痰培养阳性标本由北京市结核病防治所中心实验室作药敏测定?结果平均起始耐药率为14.5%,所耐药物以链霉素(11.0%)及异菸肼(9.8%)为主,47.9%的耐药病人耐一药,耐利福平和异菸肼二药的病人的耐药率为1.6%?起始耐药率与病人年龄及病变严重程度有关(P<0.01),与性别及空洞有无似无关(P>0.05)?结论对一个地区新发肺结核病人的起始耐药趋势进行监测是结核病控制工作的一项重要内容,可作为评价该地区结核病控制工作的重要指标之一?

关键词: 结核.肺／预防和控制, 药物耐受性

Abstract: Objective To report the monitor of initial drug resistance in new cases of pulmonary tuberculosis during the period 1984—1995 in Xicheng district of Beijing.Method The culture_positive of sputum specimens from the all new cases would be sent to the laboratory center in Beijing TB Control Institute for detection the drug sensitive test.Result The average frequency of initial drug resistance was 14.5%.The main drug resistances were to Streptomycin(11.0%) and Isoniazid(9.8%).47.9 percent of cases were resistant to any one Anti TB drug.The frequency of resistance to both RFP and INH was 1.6%.The frequency of initial drug resistance was related to the age of patient and the severe degree of the disease(P<0.01).There were no relationship between the initial drug resistance and the sex or cavity in X_ray(P>0.05).Conclusion It is one of important contents to monitor the frequency of initial drug resistance in new cases of pulmonary tuberculosis for TB control in a district.At the same time it can evaluate the TB control programme as a main index.

Key words: Drug resistance, Tuberculosis, pulmonary

沈秀萍, 徐瑞兴, 吕晶, . 北京市西城区新发肺结核病人起始耐药性监测[J]. 中国防痨杂志, 1999, 21(1): 17-19.

Shen Xiuping,Xu Ruixing,Lu Jing.. Monitor of initial drug resistance in new cases of pulmonary tuberculosis in Xicheng district,Beijing[J]. Chinese Journal of Antituberculosis, 1999, 21(1): 17-19.

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