Abstract:

Objective: To analyze the treatment outcomes and risk factors of rifampicin-sensitive pulmonary tuberculosis (PTB) patients in Chongqing City, and to provide evidence for improving treatment management measures of patients and accurately evaluating treatment outcomes. Methods: A retrospective study was conducted to include a total of 11545 rifampicin-sensitive PTB patients diagnosed and registered for treatment in Chongqing City in 2022 from the Chinese tuberculosis information management system (TBMIS). Basic demographic information and clinical data of the subjects were recorded and sorted out. Univariable and multivariable logistic regression models were used to analyze factors affecting treatment outcomes. Results: Treatment success rate of 11545 rifampicin-sensitive PTB patients was 90.26% (10421/11545).Treatment failure rate was 0.72% (83/11545), loss of follow-up rate was 1.49% (172/11545), and mortality rate was 5.52% (637/11545). Multivariable logistic regression analysis showed that ethnic minority (OR=1.573, 95%CI: 1.288-1.922), aged over 60 years old (60-74 years old:OR=3.322,95%CI:1.043-10.583;≥75 years old:OR=7.941,95%CI:2.490-25.323), etiologically positive (OR=1.419, 95%CI: 1.214-1.659), retreatment (OR=1.371, 95%CI: 1.121-1.677), severe pulmonary tuberculosis (OR=1.348, 95%CI: 1.108-1.639), adverse reactions (OR=4.183, 95%CI: 2.707-6.464), moderate and treated in secondary or lower institutions (OR=1.333, 95%CI: 1.161-1.532) were risk factors for treatment success. Being female (OR=0.659, 95%CI: 0.562-0.773) was a protective factor for treatment success. Conclusion: The treatment success rate of rifampicin-sensitive PTB patients in Chongqing City was about 90%, but special attention should be paid to patients who are ethnic minorities, over 60 years old, etiologically positive, retreatment, severe case, having adverse reactions, and treated in secondary and lower facilities.

Key words: Tuberculosis,pulmonary, Treatment outcome, Factor analysis, statistical