In vitro activities and drug resistance mechanisms of bedaquiline, clofazimine and delamanid against common pathogenic non-tuberculous mycobacteria

doi:10.3969/j.issn.1000-6621.2020.08.019

Abstract

Abstract:

Recently, the infection of non-tuberculous mycobacteria (NTM) has increased rapidly and threatened human health. NTM differentiate into many species. Species diversity makes treatment of NTM extremely difficult. Thus,it is very important to find new and effective drugs. Bedaquiline, clofazimine and delamanid showed effectiveness in treating NTM. In order to improve the understanding of drug susceptibility and drug resistance mechanism of NTM, in vitro activities and drug resistance mechanisms of bedaquiline, clofazimine and delamanid against common pathogenic are described.

Key words: Mycobacteria, atypical, Bedaquiline, Clofazimine, Delamanid, In vitro, Microbial sensitivity tests, Molecular mechanisms of pharmacological action, Review literature as topic

SUN Qing, HUANG Hai-rong, WANG Gui-rong. In vitro activities and drug resistance mechanisms of bedaquiline, clofazimine and delamanid against common pathogenic non-tuberculous mycobacteria[J]. Chinese Journal of Antituberculosis, 2020, 42(8): 880-884. doi: 10.3969/j.issn.1000-6621.2020.08.019

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