Research progress of correlation between the polymorphisms of susceptibility genes associated with the function of macrophage and tuberculosis

doi:10.3969/j.issn.1000-6621.2014.05.017

Abstract

Abstract: The function of the host macrophage causes different outcomes after Mycobacterium tuberculosis (Mtb) infection. The differences of the function of macrophage among individuals are not only the results of self-regulation in immune system, but also associated with the polymorphisms of susceptibility genes associated with the function of macrophage, including the genes influencing the killing, activation, apoptosis and other abilities of macrophage. This article reviews some achievements about the correlation between the polymorphism of susceptibility genes associated with the function of macrophage and pulmonary tuberculosis. The result shows partial polymorphism of susceptibility genes associated with the function of macrophage is correlated with the susceptibility to tuberculosis, and this correlation has not only ethical difference, but also is related to the clinical types of tuberculosis.

Key words: Macrophages, Polymorphism, genetic, Tuberculosis/genetics, Genetic predisposition to disease

JIANG Dao-bin,Qimanguli WUSHOUER. Research progress of correlation between the polymorphisms of susceptibility genes associated with the function of macrophage and tuberculosis[J]. Chinese Journal of Antituberculosis, 2014, 36(5): 385-387. doi: 10.3969/j.issn.1000-6621.2014.05.017

References

［1］World Health Organization. Global tuberculosis report 2013［M/OL］.Geneva:WHO,2013:47.
［2］全国结核病流行病学抽样调查技术指导组，全国结核病流行病学抽样调查办公室.2010年全国肺结核患病率现况调查.中华结核和呼吸杂志,2012,35（9）：665-668.
［3］Jin J,Sun L,Jiao W,et al. SLC11A1 (Formerly NRAMP1) gene polymorphisms associated with pediatric tuberculosis in China.Clin Infect Dis，2009,48（6）:733-738.
［4］安雅臣，冯福民，袁聚祥，等.NRAMP1基因INT4和3′UTR位点多态性与肺结核易患性的研究.中华流行病学杂志，2006,27（1）：37-40.
［5］纪春梅，安雅臣，李军，等.人自然抗性巨噬细胞蛋白1基因D543N和3′UTR位点多态性与中国北方汉族成人肺结核易患性的关系.中国临床康复,2006,24（10）:10-13.
［6］金婧，孙琳，焦伟伟，等. NRAMP1基因多态性与中国汉族儿童结核病易感性研究.中国当代儿科杂志，2009,11(4):283-287.
［7］熊宇，李革. NRAMP1基因多态性与重庆市汉族人群肺结核易感相关性研究.重庆医科大学学报，2010,35（12）：1820-1824.
［8］王喜，任丽君，吴芳，等.新疆维吾尔族人群结核病易感基因的多态性分析.中国现代医学杂志，2011，21（15）：1839-1845.
［9］王喜，杨跃进，吴芳,等.新疆哈萨克族人群结核病易感基因的病例对照研究.中国人兽共患病学报，2011,27（3）：207-211.
［10］吴江东，李春柱，孟宪杰,等.人NRAMP1基因3′UTR多态性与新疆汉族人群结核病易感性的研究.农垦医学，2009,31（1）：16-19.
［11］Meilang Q, Zhang Y, Zhang J,et al. Polymorphisms in the SLC11A1 gene and tuberculosis risk: a meta-analysis update. Int J Tuberc Lung Dis,2012,16(4)：437-446.
［12］Tosh K, Campbell SJ, Fielding K,et al. Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. Proc Natl Sci USA,2006,103(27):10364-10368.
［13］Lei X, Zhu H, Zha L, et al. SP110 gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-ana-lysis based on 10 624 subjects. Infect Genet Evol，2012,12(7):1473-1480.
［14］丛建妮，李革，周丹，等. Sp110基因多态性与重庆汉族肺结核遗传易感性关联性研究.卫生研究,2010,39(5):540-544.
［15］Ben-Ali M, Barbouche MR, Bousnina S，et al. Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.Clin Diagn Lab Immunol,2004,11（3）:625-626.
［16］Xue Y, Zhao ZQ, Wang HG, et al. Toll-like recptors 2 and 4 gene polymorphisms in southeastern Chinese population with tuberculosis. Int J Immunogenet，2010,37(2):135-138.
［17］Yim JJ, Lee HW, Lee HS, et al.The association between microsatellite polymorphisms in intronⅡof the human Toll-like receptor 2 gene and tuberculosis among Koreans. Genes Immun，2006，7(2):150-155.
［18］Chen YC, Hsiao CC, Chen CJ, et al. Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts.BMC Med Genet，2010，11:17.
［19］Thuong NT, Hawn TR, Thwaites GE,et al. A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis. Genes Immun，2007,8(5):422-428.
［20］Wang JJ, Xia X, Tang SD，et al. Meta-analysis on the associations of TLR2 gene polymorphisms with pulmonary tuberculosis susceptibility among Asian populations.PLoS One,2013,8(10):e75090.
［21］Kouloulias V, Plataniotis G, Kouvaris J, et al. Chemoradiotherapy combined with intracavitary hyperthermia for anal cancer: feasibility and long-term results from a phase Ⅱ randomized trial. Am J Clin Oncol，2005,28(1):91-99.
［22］Gori J, Castao R, Toziano M，et al. Intraperitoneal hyperthermic chemotherapy in ovarian cancer. Int J Gynecol Can-cer，2005,15(2):233-239.
［23］de Albuquerque AC, Rocha LQ, de Morais Batista AH，et al. Association of polymorphism +874 A/T of interferon-γ and susceptibility to the development of tuberculosis: meta-ana-lysis.Eur J Clin Microbiol Infect Dis, 2012, 31（11）:2887-2895.
［24］Cooke GS, Campbell SJ, Sillah J, et al. Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis. Am J Respir Crit Care Med，2006, 174（3）: 339-343.
［25］Mirsaeidi SM, Houshmand M, Tabarsi P, et al. Lack of association between interferon-gamma receptor-1 polymorphism and pulmonary TB in Iranian population sample. J Infect，2006，52(5):374-377.
［26］顾艺，肖婧，孙琳，等. P2X7基因多态性与结核病易感性的关联性研究：Meta分析.标记免疫分析与临床,2010,17（2）:98-101,111.
［27］Xiao J, Sun L, Yan H, et al. Metaanalysis of P2X7 gene po-lymorphisms and tuberculosis susceptibility.FEMS Immunol Med Microbiol, 2010,60（2）: 165-170.
［28］Yim JJ, Selvaraj P. Genetic susceptibility in tuberculosis. Respirology,2010,15（2）:241-256.
［29］Jamieson SE, Miller EN, Black GF,et al. Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians. Genes Immun，2004,5(1):46-57.
［30］Flores-Villanueva PO, Ruiz-Morales JA,Song CH, et al. A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. J Exp Med,2005，202(12):1649-1658.
［31］Gómez LM, Anaya JM, Vilchez JR, et al. A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis. Tuberculosis(Edinb),2007,87(4):288-294.
［32］Moller M,Nebel A, Valentonyte R, et al. Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population.Tuberculosis(Edinb),2009,89(2):189-194.
［33］Velez DR, Hulme WF, Myers JL, et al. NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans.Hum Genet,2009,126(5):643-653.

[1]	Lu Hailin, Wang Wenfei, Tao Wenhui, Lin Peicong, Chen Xinchun, Deng Guofang, Xie Shuixiang. Oleic acid upregulates the expression of perilipin 2 enhancing macrophage clearance of Mycobacterium tuberculosis [J]. Chinese Journal of Antituberculosis, 2025, 47(1): 72-76.
[2]	Wang Yilin, Wu Xiao, Pang Yu, Li Shanshan. Immunomodulatory effect of orelabrutinib in host macrophages infected with mycobacterium [J]. Chinese Journal of Antituberculosis, 2024, 46(9): 1063-1068.
[3]	Liu Haohan, Ma Zichun, Pang Yu, Li Shanshan. The function and mechanism of G protein-coupled receptors in host against Mycobacterium tuberculosis infection [J]. Chinese Journal of Antituberculosis, 2024, 46(7): 839-844.
[4]	Chen Feifei, Zheng Yongzhi, Wu Sufang, Kang Qian, Jin Chunyang. Regulating effect of reactive oxygen species/protein kinase RNA-like endoplasmic reticulum kinase signaling axis on BCG-induced ferroptosis in mouse macrophages [J]. Chinese Journal of Antituberculosis, 2024, 46(12): 1448-1458.
[5]	Zhao Yong, Liang Lili, Jiang Nan. Impact of targeted regulation of miR-144-3p by LncRNA GAS5 on macrophage apoptosis and inflammatory response in Mycobacterium tuberculosis infected macrophages [J]. Chinese Journal of Antituberculosis, 2023, 45(8): 744-751.
[6]	He Ping, Wang Yiting, Song Zexuan, Xia Hui, Wang Shengfen, He Wencong, Zheng Yang, Zhao Yanlin. Preliminary study on the gene function of Mycobacterium tuberculosis Rv2333c in macrophages [J]. Chinese Journal of Antituberculosis, 2023, 45(6): 566-574.
[7]	Shi Yuting, Dong Jing, Jia Hongyan, Zhu Chuanzhi, Yang Bin, Li Zihui, Sun Qi, Du Boping, Xing Aiying, Zhang Zongde, Pan Liping. The role of miR-99a-5p in the immune regulation of host macrophages infected by Mycobacterium tuberculosis [J]. Chinese Journal of Antituberculosis, 2023, 45(5): 464-471.
[8]	Nan Yue, Long Meizhen, Dong Yuhui, Wang Yuanzhi, Zhou Xiangmei. Research progress on macrophage glucose metabolism reprogramming in Mycobacterium tuberculosis infection [J]. Chinese Journal of Antituberculosis, 2023, 45(11): 1097-1102.
[9]	Li Yinhong, Liu Fanglin, Lu Zhenhui, Jiang Xin. Study on the mechanism of Oridonin against pathological damage of tuberculosis [J]. Chinese Journal of Antituberculosis, 2022, 44(8): 849-854.
[10]	WU Tuo-ya, SHI Jin, GUO Ji-dong, LIU Yuan-yuan, PANG Yu, LU Jie, GAO Fei. Mechanism of miR-21-3p modulating the survival of Mycobacterium tuberculosis in host macrophage [J]. Chinese Journal of Antituberculosis, 2021, 43(5): 475-481.
[11]	XIANG Hai-bin,LIANG Qiu-zhen,LI Xin-xia,SONG Xing-hua. Advances in the application of anti-tuberculosis nanoscale drug delivery system targeting macrophages [J]. Chinese Journal of Antituberculosis, 2020, 42(4): 398-403.
[12]	SUN Jin-xia,ZHANG Qing-wen,LI Yin-hong,JIANG Xin. Study of autophagy induced by myricetin in MTB infected macrophages through PI3K/Akt/mTOR signaling pathway [J]. Chinese Journal of Antituberculosis, 2020, 42(2): 101-107.
[13]	Xi CHEN,Zhong-quan LIU,Bin WANG,Hui ZHU,Lei FU,Yuan-yuan LI,Yu LU. Evaluation of antituberculosis activities of 14 antituberculosis drugs in macrophage [J]. Chinese Journal of Antituberculosis, 2019, 41(9): 993-998.
[14]	Guang-gui DING,Xing HE,Juan LIANG,Ya-ya LIU,Min OU,Jian LU,Guo-liang ZHANG. Effect of miR-20a-5p on the expression of apoptosis-related genes in Mycobacterium tuberculosis-infected human macrophages [J]. Chinese Journal of Antituberculosis, 2019, 41(7): 747-753.
[15]	Ya WANG,Chuan-you LI,Wei WANG,Shen-jie TANG. The role of macrophages in anti-tuberculosis infection [J]. Chinese Journal of Antituberculosis, 2018, 40(2): 218-221.