Research progress on macrophage glucose metabolism reprogramming in Mycobacterium tuberculosis infection

doi:10.19982/j.issn.1000-6621.20230266

Abstract

Abstract:

Macrophages are important cells involved in innate immunity and also the main target of Mycobacterium tuberculosis infection. It was found that metabolic reprogramming of immune cells is closely related to their functions. In the early stage of infection, the main change of macrophages is M1 polarized, and the mode of glucose metabolism changes from mitochondrial oxidative phosphate to aerobic glycolysis (Warburg effect), which promotes the secretion of inflammatory factors; while in the late stages of infection, the mode of glucose metabolism of macrophages changes from aerobic glycolysis to mitochondrial oxidative phosphorylation, which inhibits macrophage proinflammatory and antimicrobial responses. A comprehensive understanding of the relationship between macrophage metabolism and function during Mycobacterium tuberculosis infection is help to the development of host directed therapy. In this article, the author summarized the related research on macrophage glycometabolism reprogramming during the infection of Mycobacterium tuberculosis, in order to provide new ideas for the prevention and treatment of tuberculosis.

Key words: Mycobacterium tuberculosis, Macrophages, Immunity, cellular, Metabolism, Glycolysis, Review literature as topic

CLC Number:

R392.12
R52

Nan Yue, Long Meizhen, Dong Yuhui, Wang Yuanzhi, Zhou Xiangmei. Research progress on macrophage glucose metabolism reprogramming in Mycobacterium tuberculosis infection[J]. Chinese Journal of Antituberculosis, 2023, 45(11): 1097-1102. doi: 10.19982/j.issn.1000-6621.20230266

Figures/Tables 2

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