Abstract: Objective To ascertain the diagnostic of anti-PPD-IgG in serum and pleural effusion for the tuberculous pleural effusion.Methods Anti-PPD-IgG in serum and pleural effusion were obtained from 58 tuberculous pleural effusion cases detected by using enzyme linked immunosor bent assay (ELISA) while comparing with the positive rate of pleural biopsy and Mycobacterium tuberculosis in pleural effusion of these cases.42 cases of non tuberculous pleural effusion wewre randomly selected as control.Results The positive rate of Anti-PPD-IgG in serum (82.8%) and pleural effusion (96.6%) in tuberculous pleural effusion group were higher than that of pleural biopsy (56.9%, P<0.005 ) and Mycobacterium tuberculosis in pleural effusion (0%, P<0.005 ) and also higher than those of Anti-PPD-IgG in serum (11.9%, P<0.005 ) and pleural effusion (21.4%, P<0.005 ) of the control group,which with statistical significance.The sensitivity,specificity and accuracy of Anti-PPD-IgG in serum and pleural effusion to diagnose the tuberculous pleural effusion were 82.8%,88.1%,85.0% and 96.6%,78.6%,89.0% respectively.Conclusion The Results suggested that detection of Anti-PPD-IgG in serum and pleural effusion by ELISA method was useful for diagnosis of tuberculous pleural effusion.

Key words: Pleural effusion,tuberculous, Diagnosis, Enzyme linhed immunosor bent assay