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中国防痨杂志 ›› 2026, Vol. 48 ›› Issue (5): 561-566.doi: 10.19982/j.issn.1000-6621.20250401

• 专题笔谈 • 上一篇    下一篇

我国风湿免疫病患者结核分枝杆菌潜伏感染筛查现况与优化路径探讨

高丽, 张国钦()   

  1. 天津市结核病控制中心研究室, 天津 300041
  • 收稿日期:2025-10-13 出版日期:2026-05-10 发布日期:2026-04-27
  • 通信作者: 张国钦 E-mail:zhangguoqin@tj.gov.cn
  • 基金资助:
    天津市卫生健康行业高层次人才选拔培养工程(TJSQNYXXR-D2-117);天津市卫生健康科技项目(TJWJ2025RC019);天津市结核病控制中心科技基金(JHKJ202502)

Current status and optimization paths of latent tuberculosis infection screening in patients with rheumatic immune diseases in China

Gao Li, Zhang Guoqin()   

  1. Department of Research, Tianjin Center for Tuberculosis Control, Tianjin 300041, China
  • Received:2025-10-13 Online:2026-05-10 Published:2026-04-27
  • Contact: Zhang Guoqin E-mail:zhangguoqin@tj.gov.cn
  • Supported by:
    Tianjin High-level Talent Selection and Training Project in Health Profession(TJSQNYXXR-D2-117);Tianjin Health Research Project(TJWJ2025RC019);Science and Technology Fund of Tianjin Center for Tuberculosis Control(JHKJ202502)

摘要:

结核病是严重威胁人类健康的传染性疾病。风湿免疫病患者因自身免疫受损和药物影响,结核分枝杆菌感染风险远高于常人。因此,对该类人群进行潜伏感染筛查及预防性治疗,对控制结核病疫情、降低结核病传播意义重大。然而,临床筛查仍面临疾病特点复杂、筛查技术适配性不足且资源分配不均、临床决策不规范、社区管理缺失等多重困境。本文从风湿免疫病患者结核分枝杆菌潜伏感染的流行概况、筛查技术与资源分配、临床决策、预防性治疗与管理等方面进行综述,探索提升结核分枝杆菌感染筛查率的有效路径,从多方面深入剖析,为相关政策制定提供参考,助力改善患者预后,减轻社会医疗负担。

关键词: 风湿性疾病, 结核, 分枝杆菌感染, 综合预防, 感染控制

Abstract:

Tuberculosis is an infectious disease that poses a serious threat to human health. Patients with rheumatic diseases have much higher risk of tuberculosis infection than the general population due to impaired autoimmune systems and the influence of drugs. Screening for latent tuberculosis infection and providing preventive treatment are of great significance for controlling the condition and reducing the spread of tuberculosis. However, clinical screening still faces multiple predicaments such as complex disease characteristics, insufficient adaptability of screening technologies and uneven resource allocation, non-standard clinical decision-making, and the lack of community management. This article elaborates on the prevalence of latent tuberculosis infection in rheumatic diseases patients, screening techniques and resource allocation, clinical decision-making, preventive treatment and management, etc., to explore effective ways to increase the screening rate. It conducts in-depth analysis from multiple aspects, explores the paths to improve the screening rate, provides references for relevant policy making, helps improve patient prognosis, and reduces the burden on social medical care.

Key words: Rheumatic diseases, Tuberculosis, Mycobacterium infections, Universal precautions, Infection control

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