脓肿分枝杆菌复合群感染导致肺损伤的机制研究进展

doi:10.19982/j.issn.1000-6621.20250397

摘要/Abstract

摘要：

脓肿分枝杆菌复合群(Mycobacterium abscessus complex, MABC)具有高毒力、高耐药性,其导致肺损伤的机制较为复杂,主要由宿主免疫应答失衡及组织修复异常共同驱动。笔者对近年来有关MABC导致肺损伤的机制进行综述,重点聚焦于过度炎症反应及异常修复,以厘清疾病发展的关键节点,为未来针对特定环节的深入研究奠定基础。

关键词: 分枝杆菌,脓肿, 感染, 免疫, 综述

Abstract:

Mycobacterium abscessus complex (MABC) has high virulence and high drug resistance. The mechanisms of lung injury causing by MABC are complicated, mainly caused by the imbalance of host immune response and abnormal tissue repair. This review summarizes current researches on the mechanisms of MABC-induced lung injury, focusing especially on the roles of excessive inflammatory responses and abnormal repair processes, to identify crucial points of the disease development, to set the stage for more focused researches into particular pathogenic stages.

Key words: Mycobacterium abscessus, Infection, Immunity, Review

中图分类号:

R563
R378.91

倪盛, 沙巍, 王丽. 脓肿分枝杆菌复合群感染导致肺损伤的机制研究进展[J]. 中国防痨杂志, 2026, 48(3): 419-425. doi: 10.19982/j.issn.1000-6621.20250397

Ni Sheng, Sha Wei, Wang Li. Research progress on the mechanisms of lung injury caused by Mycobacterium abscessus[J]. Chinese Journal of Antituberculosis, 2026, 48(3): 419-425. doi: 10.19982/j.issn.1000-6621.20250397

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