2型结核分枝杆菌与肺外结核相关性的研究

中国防痨杂志 ›› 2024, Vol. 46 ›› Issue (S1): 13-16.

2型结核分枝杆菌与肺外结核相关性的研究

陈威震, 林添钰, 李津

¹联勤保障部队第900医院感染科,福州 350025

收稿日期:2024-06-03 出版日期:2024-06-30 发布日期:2024-07-03
通信作者: 李津,Email：JinLL139503@163.com
基金资助:
福建省自然科学基金面上项目（2020J011146）; 福建省自然科学基金面上项目（2023J011363）

Received:2024-06-03 Online:2024-06-30 Published:2024-07-03

摘要/Abstract

摘要： 目的: 探讨2型结核分枝杆菌与肺外结核之间的关联。方法: 以超低温保存的临床分离结核分枝杆菌为研究对象,采用RD105靶向多重PCR和NTF区域特异性PCR进行分子分型,然后分析2型及其各亚型菌株与患者临床特征之间的关联。结果: 247株结核分枝杆菌中,143株（57.9%）属于2型,包括105株（73.4%）现代亚型和38株古典亚型菌株。2型现代亚型菌株在头颈部结核的分离率仅为7.7%（1例,P<0.05）,明显低于肺结核（83例,41.5%）和肺外结核（21例,61.8%）。此外,导致多器官播散的大部分结核分枝杆菌属于现代亚型[5例（5/6）]。Logistic回归分析未发现2型或其亚型与患者的性别、年龄、抗结核治疗史有关。结论: 2型现代亚型菌株可能倾向于多器官播散,但其在头颈部结核患者的分离率较低,提示颈部淋巴结组织可能具备特异性防御功能,相关机制有待进一步研究。

关键词: 分枝杆菌,结核, 现代亚型, 结核,头颈部, 结核,肺外

陈威震, 林添钰, 李津. 2型结核分枝杆菌与肺外结核相关性的研究[J]. 中国防痨杂志, 2024, 46(S1): 13-16.

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