肉桂醛抗结核分枝杆菌作用及其机制研究进展

doi:10.19982/j.issn.1000-6621.20250089

摘要/Abstract

摘要：

耐药结核病仍然是严重的公共卫生问题,迫切需要研发新的抗结核药物。肉桂醛被认为是一种有研究价值的抗结核先导化合物,已有研究发现肉桂醛能够抑制结核分枝杆菌的生长,对结核分枝杆菌标准菌株、临床分离的敏感菌株及耐药菌株均有抗菌活性,其最低抑菌浓度值在3.12~20.3μg/ml之间。笔者综述了肉桂醛对结核分枝杆菌细胞壁、细胞膜及其应激反应系统、细胞内三磷酸腺苷水平,以及可能的蛋白靶点的作用机制,以期为结核病的治疗,以及新药和疫苗的研发提供参考。

关键词: 肉桂醛, 分枝杆菌, 结核, 药理作用分子作用机制

Abstract:

Tuberculosis ranks as the top cause of death from a single infectious disease in the world. Drug-resistant tuberculosis remains a serious public health problem. Since drug-resistant tuberculosis has become a global threat, there is an urgent need to develop new anti-tuberculosis drugs. Cinnamaldehyde is considered to be a valuable anti-tuberculosis lead compound. Studies have found that cinnamaldehyde can inhibit the growth of Mycobacterium tuberculosis and has antibacterial activity against laboratory standard strains of Mycobacterium tuberculosis, clinically isolated sensitive bacteria and drug-resistant bacteria, and its MIC value is between 3.12 and 20.3 μg/ml. Therefore, this article reviews the mechanism of cinnamaldehyde on cell wall, cell membrane and its stress response system, intracellular ATP level and possible protein targets of Mycobacterium tuberculosis, with a view to providing reference for the treatment of tuberculosis and the development of new drugs and vaccines.

Key words: Cinnamaldehyde, Mycobacterium tuberculosis, Molecular mechanisms of pharmacological action

中图分类号:

R52
R378.91

张小可, 陈玲. 肉桂醛抗结核分枝杆菌作用及其机制研究进展[J]. 中国防痨杂志, 2025, 47(9): 1220-1226. doi: 10.19982/j.issn.1000-6621.20250089

Zhang Xiaoke, Chen Ling. Research progress on the anti-tuberculosis effect and mechanism of cinnamaldehyde on Mycobacterium tuberculosis[J]. Chinese Journal of Antituberculosis, 2025, 47(9): 1220-1226. doi: 10.19982/j.issn.1000-6621.20250089

图/表 3

图1

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图2

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序号	参考文献	文献发表年份	国家/地区	肉桂醛来源	结核分枝杆菌菌株类型	MIC值 (μg/ml)	MIC测定方法
1	张越^[22]	2022	中国/贵阳	北京百灵威科技有限公司(中国)	BCG	8	微量滴定法 (刃天青)
2	Boussamba- Digombou^[21]	2022	南非/ 比勒陀利亚	Pranar?m International 公司(比利时)	H37Ra、 ATCC 25177	8	微量滴定法 (阿尔玛蓝)
3	蒋昌河^[23]	2020	中国/贵阳	从桂枝中提取	BCG、 ATCC 35734	10	刃天青显色法
4	王仁凤^[14]	2020	中国/贵阳	上海麦克林生化科技股份有限公司(中国)	H37Rv^a BCG^a	10 10	刃天青显色法
5	Mota^[20]	2019	巴西/ 福塔莱萨	Sigma-Aldrich 公司(巴西)	H37Rv^a 临床分离株(9例)^ab	19.5 15.2±5.1	微量滴定法 (刃天青)
6	Sawicki^[10]	2018	波兰/ 卢布林	Unimark Remedies 制药有限公司(印度)	H37Ra、 ATCC 25177	8	微量滴定法 (刃天青)
7	Andrade- Ochoa^[19]	2015	墨西哥/ 奇瓦瓦	Sigma-Aldrich 公司(美国)	AN5^a H37Rv^a	12.50 3.12	微量滴定法 (阿尔玛蓝)