质谱检测技术在骨关节结核诊断中的应用效能及研究进展

doi:10.19982/j.issn.1000-6621.20250038

摘要/Abstract

摘要：

受益于多组学分析的快速发展,基于蛋白质组学及代谢组学的质谱检测(mass spectrometry, MS)技术有助于骨关节结核的辅助诊断。由此得知的骨关节结核相关蛋白质标志物及代谢产物可为结核分枝杆菌与宿主互作机制的深入研究提供更多的思路,从而指导新型抗结核药物与疫苗的开发。立足于蛋白质组学及代谢组学分析,笔者围绕MS技术对骨关节结核的诊断效能及其对宿主免疫功能的影响作一综述,旨在进一步探讨其应用价值。

关键词: 结核, 骨关节, 质谱分析法, 蛋白质组学

Abstract:

With the rapid advancement of multi-omics technologies, mass spectrometry (MS)-based proteomic and metabolomic analyses have emerged as powerful tools to support the diagnosis of osteoarticular tuberculosis. The identification of disease-specific protein biomarkers and metabolites not only enhances diagnostic accuracy but also offers critical insights into the complex interplay between Mycobacterium tuberculosis and host immune responses. These insights hold promise for guiding the development of novel anti-tuberculosis drugs and vaccines. This review synthesizes current findings on the diagnostic utility of MS in osteoarticular tuberculosis and highlights recent progress in understanding how MS-derived biomarkers influence host immune function, thereby underscoring the potential of MS in translational and clinical applications.

Key words: Tuberculosis, osteoarticular, Mass spectrometry, Proteomics

中图分类号:

R529.2
R392

毛莉蓉, 聂艳辉, 安红娟, 王睿岚, 董恩军, 苏悦, 赵文娟, 杜经丽, 安慧茹. 质谱检测技术在骨关节结核诊断中的应用效能及研究进展[J]. 中国防痨杂志, 2025, 47(7): 940-946. doi: 10.19982/j.issn.1000-6621.20250038

Mao Lirong, Nie Yanhui, An Hongjuan, Wang Ruilan, Dong Enjun, Su Yue, Zhao Wenjuan, Du Jingli, An Huiru. Application efficacy and research progress of mass spectrometry detection technology in the diagnosis of osteotuberculosis[J]. Chinese Journal of Antituberculosis, 2025, 47(7): 940-946. doi: 10.19982/j.issn.1000-6621.20250038

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