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中国防痨杂志 ›› 2025, Vol. 47 ›› Issue (11): 1528-1534.doi: 10.19982/j.issn.1000-6621.20250299

• 综述 • 上一篇    

耐多药结核病患者密切接触者抗结核预防性治疗研究进展

祖之鹏1, 陈海婷2, 陈园园3, 聂文娟4, 徐凯进5, 阮巧玲6, 柳正卫1,2, 周琳1, 王晓萌1(), 高磊7()   

  1. 1浙江省疾病预防控制中心结核病预防控制所,杭州 310051
    2杭州医学院公共卫生系,杭州 310053
    3杭州市红十字会医院结核病诊疗中心,杭州 310003
    4首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所结核科,北京 101149
    5浙江大学附属第一医院感染科,杭州 310006
    6复旦大学附属华山医院感染科,上海 200040
    7中国防痨协会,北京 100710
  • 收稿日期:2025-07-23 出版日期:2025-11-10 发布日期:2025-10-30
  • 通信作者: 王晓萌,高磊 E-mail:xmwang@cdc.zj.cn;gaolei615@126.com
  • 基金资助:
    浙江省自然基金项目(TGY23H190002);浙江省医药卫生科技计划项目(2023KY645)

Research progress on tuberculosis preventive treatment for close contacts of multidrug-resistant tuberculosis patients

Zu Zhipeng1, Chen Haiting2, Chen Yuanyuan3, Nie Wenjuan4, Xu Kaijin5, Ruan Qiaoling6, Liu Zhengwei1,2, Zhou Lin1, Wang Xiaomeng1(), Gao Lei7()   

  1. 1Department of Tuberculosis Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
    2School of Public Health, Hangzhou Medical College, Hangzhou 310053, China
    3Tuberculosis Diagnosis and Treatment Center, Hangzhou Red Cross Hospital, Hangzhou 310003, China
    4Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University/Beijing Institute of Tuberculosis and Thoracic Tumor, Beijing 101149, China
    5Department of Infectious Diseases, The First Affiliated Hospital of Zhejiang University, Hangzhou 310006, China
    6Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
    7Chinese Antituberculosis Association, Beijing 100710, China
  • Received:2025-07-23 Online:2025-11-10 Published:2025-10-30
  • Contact: Wang Xiaomeng,Gao Lei E-mail:xmwang@cdc.zj.cn;gaolei615@126.com
  • Supported by:
    Zhejiang Provincial Natural Science Foundation Project(TGY23H190002);Zhejiang Provincial Medical and Health Science and Technology Plan Project(2023KY645)

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摘要：

耐多药结核病(multidrug-resistant tuberculosis,MDR-TB)患者密切接触者的抗结核预防性治疗(tuberculosis preventive treatment,TPT)是降低其发展为活动性结核病风险的关键干预措施。早期实施有效的预防对保护个体健康及遏制耐药结核病传播具有至关重要的意义。目前,MDR-TB患者密切接触者的TPT方案单一,且在我国存在证据缺口。因此,笔者围绕当前针对MDR-TB患者密切接触者进行TPT领域的核心议题,包括国内外指南依据,可用药物方案及其有效性与安全性等国内外研究现状进行综述,以期为推动我国研发更优化的MDR-TB患者密切接触者管理策略、研发更安全高效的短程预防方案提供科学参考与决策依据。

关键词: 结核, 抗药性,多种,细菌, 预防和防护用药, 治疗应用

Abstract:

Tuberculosis preventive treatment (TPT) among close contacts of multidrug-resistant tuberculosis (MDR-TB) patients is a critical intervention to reduce their risk of developing active tuberculosis. Early implementation of effective prevention is crucial for protecting individual health and curbing the spread of drug-resistant tuberculosis. Currently, the TPT regimen for close contacts of MDR-TB patients is limited, and there is a lack of evidence in China. Therefore, this review focuses on core issues in the field of TPT for MDR-TB close contacts, including domestic and international guideline recommendations, available drug regimens, and their efficacy and safety based on current research. The aim is to provide scientific references and decision-making support for developing more optimized management strategies for MDR-TB close contacts and safer, more effective short-course preventive regimens in China.

Key words: Tuberculosis, Drug resistance, multiple, bacterial, Protective agents, Therapeutic uses

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