实验性大鼠结核病模型的特点

中国防痨杂志 ›› 2001, Vol. 23 ›› Issue (4): 248-249.

实验性大鼠结核病模型的特点

陈虹¹；罗永艾¹；向理科²；刘精华¹；黄习臣¹；

1.重庆医科大学临床医学院肺科重庆 400016；2.重庆医科大学基础医学院病理教研室重庆 400016；

出版日期:2001-04-10 发布日期:2001-11-03

Features of experimental tuberculosis in Wistar rats

CHEN Hong,et al.

College of Clinic Medicine,Chongqing Medical University,Chongqing 400016

Online:2001-04-10 Published:2001-11-03

摘要/Abstract

摘要： 目的　探讨感染了结核菌的Wistar大鼠的实验特点。方法用标准人型结核菌株H₃₇Rv 0.01mg经尾静脉注入Wistar大鼠，6周后剖杀大鼠，观察肺、肝、脾组织大体病变及镜下特点，肺组织匀浆培养有无结核菌落生长。结果实验组大鼠肺组织可见明显的结核病变，感染成功率100%，肝、脾组织无结核病变。结论 Wistar大鼠对结核菌敏感，可作为结核病实验的动物模型。

关键词: 大鼠,近交系, 结核,肺/微生物学, 分支杆菌,结核

Abstract: Objective To observe the features of experimental tuberculosis in Wistar rats.Methods Wistar rats were intravenously injected with H₃₇R_v.They were sacrificed six weeks later to observe pathomorphology changes in lung,liver,and spleen tissues.We also did Mycobacterium tuberculosis culture of lung tissues.Results There are typical tubercle lesions in the lung tissues of experimental rats but not in liver,and spleen tissues,and 100% of the positive controls were infected.Conclusion Wistar rats can be infected by Mycobacterium tuberculosis and can be used as animal model of experimental tuberculosis.

Key words: rat,Wistar, tuberculosis,pulmonary/microbiology, Mycobacterium tuberculosis

陈虹,罗永艾,向理科,刘精华,黄习臣,. 实验性大鼠结核病模型的特点[J]. 中国防痨杂志, 2001, 23(4): 248-249.

CHEN Hong,et al.. Features of experimental tuberculosis in Wistar rats[J]. Chinese Journal of Antituberculosis, 2001, 23(4): 248-249.