三种喹诺酮类药物抗结核分支杆菌最低抑菌浓度分布状况研究

中国防痨杂志 ›› 2001, Vol. 23 ›› Issue (4): 222-224.

三种喹诺酮类药物抗结核分支杆菌最低抑菌浓度分布状况研究

张旭霞；王苏民；高微微；

北京市结核病胸部肿瘤研究所北京 101149；

出版日期:2001-04-10 发布日期:2001-11-03

Study on MICs’ distribution of three kinds of fluoroquinlone against Mycobacterium tuberculosis

ZHANG Xu xia,WANG Su min,GAO Wei wei.

Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149

Online:2001-04-10 Published:2001-11-03

摘要/Abstract

摘要： 目的　探索三种喹诺酮类药物抗结核分支杆菌的抑菌浓度，分析三种药物的最低抑菌浓度(minimal inhibitory concentration，MIC)分布。方法采用试管等倍稀释法测药物MIC。结果未用喹诺酮类药物的结核菌株21株中20株 (95.2%)的MIC分布与H₃₇Rv的MIC值相近。应用喹诺酮类药物于4周的结核菌株15株中13株 (86.7%)MIC分布与未用药组MIC分布相同，用喹诺酮类药物4周以上的结核菌株16株中15株 (93.7%)的MIC的分布与未用药组的MIC分布相比，增高的趋势明显。结论长时间应用喹诺酮类药物可能会引起MIC的增高而影响临床疗效。

关键词: 分支杆菌,结核, 喹喏酮类/药代动力学

Abstract: Objective To explore the MICs’ distribution of ofloxacin,levofloxacin and ciprofloxacin against clinical isolate of Mycobacterium tuberculosis in vitro strains.Methods The MICs of these drugs were determined by equivalent dilution method.Results Of 21 clinical isolates of M.tuberculosis not previously exposed,and of 15 clinical isolates previously exposed within 4 weeks to these drugs,the MICs of 20 (95.2%) and 13(86.7%) respectively were closed to that of Mycobacterium tuberculosis H₃₇Rv’s,of 16 isolates of M.tuberculosis previously exposed beyond 4 weeks,MICs of 15 isolates (93.7%) were higher than that of H₃₇Rv.Conclusion If the three drugs were treated patients with tuberculosis for a long time,the MICs of M.Tuberculosis of these drugs might be increased.

Key words: Mycobacterium,tuberculosis, Fluoroquinlones/pharmacokin

张旭霞,王苏民,高微微,. 三种喹诺酮类药物抗结核分支杆菌最低抑菌浓度分布状况研究[J]. 中国防痨杂志, 2001, 23(4): 222-224.

ZHANG Xu xia,WANG Su min,GAO Wei wei.. Study on MICs’ distribution of three kinds of fluoroquinlone against Mycobacterium tuberculosis[J]. Chinese Journal of Antituberculosis, 2001, 23(4): 222-224.