血红素加氧酶-1在肺结核疾病进展中的研究进展

doi:10.19982/j.issn.1000-6621.20260205

摘要/Abstract

摘要：

血红素加氧酶-1(heme oxygenase-1, HO-1)是血红素代谢过程中的关键酶,其在氧化应激、免疫应答及细胞代谢等过程中发挥重要调控作用,近年来已成为结核病研究的热点问题。笔者从HO-1的生物学特性出发,系统阐述其在肺结核疾病进展过程中的双重作用。在此基础上,进一步探讨HO-1作为潜在生物学标志物在肺结核诊断、治疗及预后评估中的预测价值,并梳理靶向调控HO-1宿主导向疗法策略的研究进展,包括药理调控手段及其与现有抗结核药物的协同作用等。最后,针对当前该领域研究中存在的争议与关键问题进行分析与展望,以期为结核病新型诊疗策略的研发和防控实践的优化提供理论依据和研究方向。

关键词: 血红素加氧酶-1, 结核, 肺, 宿主导向疗法

Abstract:

Heme oxygenase-1 (HO-1) is a key enzyme in heme metabolism. It plays a critical regulatory role in processes such as oxidative stress, immune response, and cellular metabolism. In recent years, HO-1 has become a focal point of tuberculosis research. Starting from the biological characteristics of HO-1, this article systematically elucidates its dual role in the development of pulmonary tuberculosis. On this basis, we further explore the predictive value of HO-1 as a potential biomarker for tuberculosis diagnosis, treatment guidance, and prognosis assessment. The article also reviews recent advances in host-directed therapeutic strategies targeting HO-1, including pharmacological interventions and their synergistic effects with existing anti-tuberculosis drugs. Finally, we analyze the current controversies and key challenges in the field and provide future perspectives. The aim is to offer a theoretical foundation and research directions for the development of novel diagnostic and therapeutic approaches, as well as for the improvement of tuberculosis prevention and control practices.

Key words: Heme oxygenase-1, Tuberculosis, pulmonary, Host-directed therapy

中图分类号:

R521

孟蝶, 朱亮. 血红素加氧酶-1在肺结核疾病进展中的研究进展[J]. 中国防痨杂志, 2026, 48(9): 1415-1421. doi: 10.19982/j.issn.1000-6621.20260205

Meng Die, Zhu Liang. Research progress of heme oxygenase-1 in tuberculosis[J]. Chinese Journal of Antituberculosis, 2026, 48(9): 1415-1421. doi: 10.19982/j.issn.1000-6621.20260205

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