3D打印人工骨在脊柱结核骨缺损植骨中应用的研究进展

doi:10.19982/j.issn.1000-6621.20230361

中国防痨杂志 ›› 2024, Vol. 46 ›› Issue (9): 1104-1108.doi: 10.19982/j.issn.1000-6621.20230361

3D打印人工骨在脊柱结核骨缺损植骨中应用的研究进展

杨军¹, 邓强¹(), 张彦军², 郭铁峰², 李军杰², 杜健强³, 田宏晶³, 刘鑫峰³

¹甘肃省中医院医务处,兰州 730050
²甘肃省中医院脊柱骨二科,兰州 730050
³甘肃中医药大学研究生院,兰州 730000

收稿日期:2023-10-11 出版日期:2024-09-10 发布日期:2024-08-30
通信作者: 邓强,Email:znzsjzez@163.com
基金资助:
2023年甘肃省卫生健康行业科研项目(GSWSKY2023-27);2021年甘肃省财政转移支付地方项目(20210140305);2022年国家中医优势专科建设项目(220028);2016年兰州市科技计划项目(2016-3-114)

Research progress on the application of 3D printed artificial bone in spinal tuberculosis bone defect grafting

Yang Jun¹, Deng Qiang¹(), Zhang Yanjun², Guo Tiefeng², Li Junjie², Du Jianqiang³, Tian Hongjing³, Liu Xinfeng³

¹Medical Services, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
²Second Department of Spine and Bone, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
³Graduate School of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

Received:2023-10-11 Online:2024-09-10 Published:2024-08-30
Contact: Deng Qiang,Email:znzsjzez@163.com
Supported by:
Gansu Provincial Health Industry Research Project in 2023(GSWSKY2023-27);The Local Project of Fiscal Transfer Payment in Gansu Province in 2021(20210140305);National TCM Advantage Specialty Construction Project in 2022(220028);2016 Lanzhou Science and Technology Plan Project(2016-3-114)

摘要/Abstract

摘要：

脊柱结核骨缺损是临床上常见的结核性感染性病灶,具有手术难度大、治疗周期长、并发症多等特点,快速高效促进病灶骨缺损修复的植骨材料是临床医师寻求的新材料。近年来,3D打印技术在医疗领域应用越来越广泛,在骨组织工程支架制备领域展现出了良好的发展前景。作者对3D打印载药人工骨支架修复脊柱结核骨缺损相关研究进行综述,并阐述了3D打印载药人工骨优化策略及未来发展方向。

关键词: 3D打印, 人工骨, 结核,脊柱, 骨修复

Abstract:

Spinal tuberculosis bone defect is a common tuberculous infectious lesion in clinical practice. It has the characteristics of being difficult to perform operation on, and having long treatment cycle and many complications. Bone graft materials that could quickly and efficiently promote the repair of bone defects are new materials sought by all clinicians. In recent years, 3D printing technology has been more and more widely used in the medical field, and has shown a good development prospect in the field of bone tissue engineering scaffold preparation. The author reviews researches on the repair of spinal tuberculosis bone defects with 3D printing drug-loaded artificial bone scaffolds, and expounds the optimization strategy and future development direction of 3D printing drug-loaded artificial bone.

Key words: 3D printing, Artificial bone, Tuberculosis, spinal, Bone repair

中图分类号:

R529.2

杨军, 邓强, 张彦军, 郭铁峰, 李军杰, 杜健强, 田宏晶, 刘鑫峰. 3D打印人工骨在脊柱结核骨缺损植骨中应用的研究进展[J]. 中国防痨杂志, 2024, 46(9): 1104-1108. doi: 10.19982/j.issn.1000-6621.20230361

Yang Jun, Deng Qiang, Zhang Yanjun, Guo Tiefeng, Li Junjie, Du Jianqiang, Tian Hongjing, Liu Xinfeng. Research progress on the application of 3D printed artificial bone in spinal tuberculosis bone defect grafting[J]. Chinese Journal of Antituberculosis, 2024, 46(9): 1104-1108. doi: 10.19982/j.issn.1000-6621.20230361

参考文献 44

[1]	Heyde CE, Lubbert C, Wendt S, et al. Spinal Tuberculosis. Z Orthop Unfall, 2022, 160(1):74-83. doi:10.1055/a-1285-4994.
[2]	Ruparel S, Tanaka M, Mehta R, et al. Surgical Management of Spinal Tuberculosis-The Past, Present, and Future. Diagnostics (Basel), 2022, 12(6):1307. doi:10.3390/diagnostics12061307.
[3]	Hua L, Qian H, Lei T, et al. 3D-Printed Porous Tantalum Coated with Antitubercular Drugs Achieving Antibacterial Properties and Good Biocompatibility. Macromol Biosci, 2022, 22(1):e2100338. doi:10.1002/mabi.202100338.
[4]	Nauth A, Schemitsch E, Norris B, et al. Critical-Size Bone Defects: Is There a Consensus for Diagnosis and Treatment?. J Orthop Trauma, 2018,32 Suppl 1:S7-S11. doi:10.1097/BOT.0000000000001115.
[5]	刘忠军. 3D打印技术在脊柱外科中的应用价值. 中国脊柱脊髓杂志, 2020, 30(9):772-773. doi:10.3969/j.issn.1004-406X.2020.09.01.
[6]	石磊, 栗向东, 王玲, 等. 3D打印个体化人工椎体在多节段脊柱肿瘤切除后脊柱稳定性重建中的应用. 中国脊柱脊髓杂志, 2020, 30(9):782-790. doi:10.3969/j.issn.1004-406X.2020.09.03.
[7]	黄杜军. 3D打印假体在脊柱肿瘤切除术后重建的早期效果观察. 福州:福建医科大学, 2021.
[8]	Zhang M, Matinlinna JP, Tsoi J, et al. Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview. J Orthop Translat, 2020, 22:26-33. doi:10.1016/j.jot.2019.09.005.
[9]	Zhang T, Wei Q, Zhou H, et al. Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6Al4V for treating methicillin-resistant Staphylococcus aureus bone infection and enhancing osteogenesis in a rabbit tibia osteomyelitis model. Biomater Sci, 2020, 8(11):3106-3115. doi:10.1039/c9bm01968e.
[10]	Wang Z, Maimaitiaili A, Wang T, et al. Rifapentine Polylactic Acid Sustained-Release Microsphere Complex for Spinal Tuberculosis Therapy: Preparation, in vitro and in vivo Studies. Infect Drug Resist, 2021, 14:1781-1794. doi:10.2147/IDR.S304864.
[11]	Zhang Z, Wu L, Li H, et al. Drug Release Characteristics and Tissue Distribution of Rifapentine Polylactic Acid Sustained-Release Microspheres in Rabbits after Paravertebral Implantation. Iran Red Crescent Med J, 2016, 18(11):e38661. doi:10.5812/ircmj.38661.
[12]	Fang X, Dong JF, Wang Q, et al. Preparation and Biocompa-tibility Evaluation of Nanoscale Isoniazide-Loaded Mineralized Collagen Implants for Tuberculous Bone and Joint Repair. J Biomed Nanotechnol, 2022, 18(1):193-201. doi:10.1166/jbn.2022.3218. pmid: 35180912
[13]	Zhang D, Liu W, Wu XD, et al. Efficacy of novel nano-hydroxyapatite/polyurethane composite scaffolds with silver phosphate particles in chronic osteomyelitis. J Mater Sci Mater Med, 2019, 30(6):59. doi:10.1007/s10856-019-6261-7.
[14]	张晓宇, 陈琪, 杨兴, 等. 聚乳酸-羟基乙酸共聚物微球在骨组织工程中的应用. 中国组织工程研究, 2023, 27(30):4896-4903. doi:10.12307/2023.559.
[15]	张赫, 张泽林, 蔡振存. 3D打印在骨盆骨折的应用进展. 中国矫形外科杂志, 2023, 31(6):520-523. doi:10.3977/j.issn.1005-8478.2023.06.08.
[16]	路康, 李洁, 唐翔宇, 等. 3D打印个体化骨科内植物的临床应用与研究进展. 中华骨与关节外科杂志, 2023, 16(1):77-84. doi:10.3969/j.issn.2095-9958.2023.01.11.
[17]	Senkoylu A, Daldal I, Cetinkaya M. 3D printing and spine surgery. J Orthop Surg (Hong Kong), 2020, 28(2):616587369. doi:10.1177/2309499020927081.
[18]	Li K, Liu Z, Li X, et al. 3D printing-assisted surgery for proximal humerus fractures: a systematic review and meta-analysis. Eur J Trauma Emerg Surg, 2022, 48(5):3493-3503. doi:10.1007/s00068-021-01851-5.
[19]	Jeon S, Lee SH, Ahmed SB, et al. 3D cell aggregate printing technology and its applications. Essays Biochem, 2021, 65(3):467-480. doi:10.1042/EBC20200128. pmid: 34223609
[20]	Li B, Zhang M, Lu Q, et al. Application and Development of Modern 3D Printing Technology in the Field of Orthopedics. Biomed Res Int, 2022,2022:8759060. doi:10.1155/2022/8759060.
[21]	刘宸希, 康红军, 吴金珠, 等. 3D打印技术及其在医疗领域的应用. 材料工程, 2021, 49(6):66-76. doi:10.11868/j.issn.1001-4381.2019.001042.
[22]	Jing Z, Zhang T, Xiu P, et al. Functionalization of 3D-printed titanium alloy orthopedic implants: a literature review. Biomed Mater, 2020, 15(5):52003. doi:10.1088/1748-605X/ab9078. pmid: 32369792
[23]	白见福. 熔融电流体3D打印载药支架用于骨修复中抗感染的研究. 广州: 广东工业大学, 2021. doi:10.27029/d.cnki.ggdgu.2021.001505.
[24]	Chae S, Cho D. Biomaterial-based 3D bioprinting strategy for orthopedic tissue engineering. Acta Biomaterialia, 2023, 156:4-20. doi:10.1016/j.actbio.2022.08.004.
[25]	宋涛. 3D打印个性化聚已内酯/β-磷酸三钙/碳纳米管复合多孔骨组织支架的制备及其性能评价. 青岛:青岛大学, 2020.
[26]	张正也, 刘晓奇, 庄金鹏, 等. 3D打印钛合金在骨科的临床应用及进展. 实用骨科杂志, 2021, 27(9):820-824. doi:10.13795/j.cnki.sgkz.2021.09.011.
[27]	李珊, 刘超, 晏怡果. 医用金属材料在骨科应用中的生物功能化. 中国组织工程研究, 2021, 25(34):5523-5529. doi:10.12307/2021.250.
[28]	甄珍, 王健, 奚廷斐, 等. 3D打印钛金属骨科植入物应用现状. 中国生物医学工程学报, 2019, 38(2):240-251. doi:10.3969/j.issn.0258-8021.2019.02.014.
[29]	刘艳成, 李爽, 张净宇, 等. 多孔隙3D打印人工椎体在脊柱结核重建手术中的应用. 中国脊柱脊髓杂志, 2022, 32(11):1027-1033.
[30]	齐大虎. 3D打印镁掺杂β-磷酸三钙生物陶瓷支架修复骨缺损的机制及应用研究. 武汉:华中科技大学, 2022.
[31]	曹雪飞. 3D打印β-磷酸三钙负载INH、RFP/PLGA缓释微球的生物安全性及成骨作用的研究. 兰州:兰州大学, 2016.
[32]	朱禧. 3D打印载PaMZ/BMP-2的纳米HA人工骨的构建及其成骨和抗结核性能研究. 银川:宁夏医科大学, 2022.
[33]	刘昌昊. 载PaMZ/BMP-2的nHA抗结核人工骨体外对兔BMSCs成骨性能影响的研究. 银川:宁夏医科大学, 2021.
[34]	刘昌昊, 郑建平, 施建党, 等. 负载抗结核药物与骨形态发生蛋白2缓释微球的3D打印人工骨能促进骨髓间充质干细胞成骨. 中国组织工程研究, 2021, 25(28):4447-4453. doi:10.12307/2021.056.
[35]	朱禧, 唐学峰, 施建党, 等. 3D打印载PaMZ/BMP-2的nHA抗结核人工骨体外缓释及抗结核性能研究. 中国脊柱脊髓杂志, 2022, 32(8):735-742.
[36]	Liu H, Zhu H, Cheng L, et al. TCP/PLGA composite scaffold loaded rapamycin in situ enhances lumbar fusion by regulating osteoblast and osteoclast activity. J Tissue Eng Regen Med, 2021, 15(5):475-486. doi:10.1002/term.3186. pmid: 33686790
[37]	Yahia S, Khalil IA, Ghoniem MG, et al. 3D-bioimplants mimicking the structure and function of spine units for the treatment of spinal tuberculosis. RSC Adv, 2023, 13(25):17340-17353. doi:10.1039/d3ra02351f. pmid: 37304785
[38]	Roseti L, Parisi V, Petretta M, et al. Scaffolds for Bone Tissue Engineering: State of the art and new perspectives. Mater Sci Eng C Mater Biol Appl, 2017, 78:1246-1262. doi:10.1016/j.msec.2017.05.017.
[39]	岳晓锟, 米雪莲, 苏治, 等. 3D打印用于骨缺损治疗的研究进展. 中华骨与关节外科杂志, 2023, 16(1):58-65. doi:10.3969/j.issn.2095-9958.2023.01.08.
[40]	Vella JB, Trombetta RP, Hoffman MD, et al. Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure. J Biomed Mater Res A, 2018, 106(3):663-672. doi:10.1002/jbm.a.36270. pmid: 29044984
[41]	巩栋, 马永海, 杨新乐, 等. 3D打印β-磷酸三钙负载聚乳酸-羟基乙酸共聚物抗结核药物缓释微球细胞毒性及对BMSCs成骨分化影响的研究. 中国修复重建外科杂志, 2018, 32(9):1131-1136. doi:10.7507/1002-1892.201803067.
[42]	孟磊, 甄平, 梁晓燕. 3D打印多孔β-磷酸三钙负载聚乳酸-羟基乙酸共聚物抗结核药物缓释微球复合材料:构建及细胞毒性评价. 中国组织工程研究, 2016, 20(25):3750-3756. doi:10.3969/j.issn.2095-4344.2016.25.016.
[43]	Zhu M, Li K, Zhu Y, et al. 3D-printed hierarchical scaffold for localized isoniazid/rifampin drug delivery and osteoarticular tuberculosis therapy. Acta Biomater, 2015, 16:145-155. doi:10.1016/j.actbio.2015.01.034. pmid: 25653217
[44]	Zheng C, Attarilar S, Li K, et al. 3D-printed HA15-loaded beta-Tricalcium Phosphate/Poly (Lactic-co-glycolic acid) Bone Tissue Scaffold Promotes Bone Regeneration in Rabbit Radial Defects. Int J Bioprint, 2021, 7(1):317. doi:10.18063/ijb.v7i1.317.

3D打印人工骨在脊柱结核骨缺损植骨中应用的研究进展

Research progress on the application of 3D printed artificial bone in spinal tuberculosis bone defect grafting

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 44

相关文章 2

编辑推荐

Metrics

本文评价

友情链接

[1]	王洪波, 曹永军, 杜丽娜. 导航技术和3D打印共面穿刺模板对肺微小结节的诊断价值[J]. 中国防痨杂志, 2024, 46(S1): 97-99.
[2]	郑佳妹,黄丽霞,王敏,金阳辉. 应用3D打印技术的宣传教育对胸椎结核患者术前改善负性情绪的影响[J]. 中国防痨杂志, 2018, 40(5): 494-498.