Chinese Journal of Antituberculosis ›› 2021, Vol. 43 ›› Issue (9): 952-960.doi: 10.3969/j.issn.1000-6621.2021.09.016
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ZHOU Ying-yu, FU Lei, ZHANG Wei-yan, WANG Bin, CHEN Xi, LU Yu(), CHEN Xiao-you()
Received:
2021-05-08
Online:
2021-09-10
Published:
2021-09-07
Contact:
LU Yu,CHEN Xiao-you
E-mail:luyu4876@hotmail.com;chenxy1998@hotmail.com
ZHOU Ying-yu, FU Lei, ZHANG Wei-yan, WANG Bin, CHEN Xi, LU Yu, CHEN Xiao-you. Analysis and comparative study on the virulence of several drug-resistant Mycobacterium tuberculosis[J]. Chinese Journal of Antituberculosis, 2021, 43(9): 952-960. doi: 10.3969/j.issn.1000-6621.2021.09.016
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菌株 | 耐药类型 | Lzd(μg/ml) | PA-824(μg/ml) | PBTZ-169(ng/ml) |
---|---|---|---|---|
H37Rv | - | 0.25 | 0.07 | 0.31 |
H37Ra | - | 0.06 | 0.03 | 0.22 |
L1 | 单耐Lzd | 13.59a | 0.15 | - |
P1 | 单耐PA-824 | 0.22 | >20.00a | - |
PL1 | 同时耐Lzd和PA-824 | 12.37a | >20.00a | - |
PL2 | 同时耐Lzd和PA-824 | 10.93a | >20.00a | - |
PL3 | 同时耐Lzd和PA-824 | 8.51a | >20.00a | - |
169-1 | 单耐PBTZ-169 | - | - | 6.11a |
169-2 | 单耐PBTZ-169 | - | - | >400.00a |
169-3 | 单耐PBTZ-169 | - | - | >400.00a |
菌株 | 第0天 | 第3天 | 第7天 | 第14天 | 第21天 | 第28天 |
---|---|---|---|---|---|---|
H37Rv | 5.148±0.121 | 6.856±0.084 | 6.675±0.065 | 7.044±0.264 | 7.370±0.142 | 7.256±0.113 |
H37Ra | 5.090±0.079 | 6.556±0.126 | 6.439±0.239 | 6.694±0.058 | 7.027±0.046 | 7.137±0.221 |
L1 | 5.029±0.011 | 6.077±0.031 | 6.854±0.072 | 7.118±0.035 | 7.233±0.021 | 7.011±0.161 |
P1 | 5.128±0.070 | 5.671±0.093 | 6.826±0.090 | 7.016±0.039 | 7.221±0.026 | 7.255±0.037 |
PL1 | 5.039±0.036 | 5.951±0.024 | 7.019±0.026 | 7.113±0.024 | 7.155±0.043 | 7.260±0.074 |
PL2 | 5.008±0.030 | 6.259±0.027 | 7.159±0.068 | 7.103±0.009 | 7.423±0.002 | 7.212±0.085 |
PL3 | 5.018±0.240 | 6.223±0.037 | 6.892±0.087 | 6.841±0.044 | 7.126±0.026 | 7.430±0.126 |
169-1 | 5.013±0.039 | 6.503±0.175 | 6.969±0.276 | 7.190±0.082 | 7.783±0.147 | 7.287±0.081 |
169-2 | 5.079±0.115 | 6.598±0.069 | 6.826±0.127 | 7.015±0.065 | 7.537±0.168 | 7.327±0.261 |
169-3 | 5.227±0.077 | 6.865±0.174 | 7.024±0.082 | 6.948±0.059 | 7.483±0.072 | 7.270±0.201 |
15833 | 5.112±0.097 | 6.207±0.019 | 6.998±0.069 | 7.328±0.073 | 7.530±0.078 | 7.470±0.115 |
16030 | 5.363±0.044 | 6.146±0.036 | 7.243±0.038 | 7.428±0.036 | 7.429±0.062 | 7.183±0.154 |
17080 | 5.502±0.394 | 6.361±0.019 | 7.125±0.020 | 7.409±0.038 | 7.709±0.142 | 7.223±0.386 |
30744 | 5.246±0.205 | 6.411±0.108 | 6.243±0.074 | 6.548±0.103 | 6.663±0.230 | 6.660±0.104 |
菌株种类 | CFU计数 (log10CFU/ml, | t值 | P值 |
---|---|---|---|
H37Rv | 6.207±0.028 | - | - |
L1 | 6.134±0.057 | -1.506 | 0.207 |
P2 | 6.125±0.095 | 1.144 | 0.316 |
PL1 | 5.763±0.197 | 4.796 | 0.009 |
PL2 | 5.907±0.053 | 7.042 | 0.020 |
PL3 | 5.661±0.083 | 9.113 | 0.001 |
169-1 | 5.800±0.385 | 1.501 | 0.271 |
169-2 | 5.933±0.221 | 1.710 | 0.225 |
169-3 | 5.938±0.147 | 2.541 | 0.064 |
15833 | 5.180±0.074 | 17.932 | <0.01 |
16030 | 5.571±0.029 | 12.758 | <0.01 |
30744 | 5.550±0.073 | 12.034 | <0.01 |
17080 | 5.446±0.099 | 10.241 | 0.001 |
H37Ra | 4.634±0.286 | 7.715 | 0.020 |
菌株种类 | 吸光度值(A490) 比值( | t值 | P值 |
---|---|---|---|
H37Rv | 0.958±0.025 | - | - |
L1 | 0.329±0.015 | 44.005 | <0.01 |
P2 | 0.483±0.017 | 32.698 | <0.01 |
PL1 | 0.328±0.046 | 27.713 | <0.01 |
PL2 | 0.455±0.075 | 15.171 | <0.01 |
PL3 | 0.283±0.041 | 31.798 | <0.01 |
169-1 | 0.258±0.044 | 31.472 | <0.01 |
169-2 | 0.374±0.080 | 16.515 | <0.01 |
169-3 | 0.311±0.097 | 15.570 | <0.01 |
15833 | 0.252±0.039 | 27.269 | <0.01 |
16030 | 0.412±0.078 | 16.788 | <0.01 |
30744 | 0.247±0.022 | 38.244 | <0.01 |
17080 | 0.358±0.054 | 24.238 | <0.01 |
H37Ra | 0.233±0.009 | 54.247 | <0.01 |
组别 | 15833 | 16030 | 30744 | 17080 | ||||
---|---|---|---|---|---|---|---|---|
χ2值 | P值 | χ2值 | P值 | χ2值 | P值 | χ2值 | P值 | |
H37Rv | 25.721 | 0.000 | 25.721 | 0.000 | 25.721 | 0.000 | 22.208 | 0.000 |
H37Ra | 26.767 | 0.000 | 26.134 | 0.000 | 14.488 | 0.000 | 25.545 | 0.000 |
15833 | - | - | 1.185 | 0.276 | 22.557 | 0.000 | 7.704 | 0.006 |
16030 | 1.185 | 0.276 | - | - | 25.011 | 0.000 | 8.974 | 0.003 |
30744 | 22.557 | 0.000 | 25.011 | 0.000 | - | - | 11.240 | 0.001 |
17080 | 7.704 | 0.006 | 8.974 | 0.003 | 11.240 | 0.001 | - | - |
组别 | L1 | P1 | PL1 | PL2 | PL3 | 169-1 | 169-2 | 169-3 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
χ2值 | P值 | χ2值 | P值 | χ2值 | P值 | χ2值 | P值 | χ2值 | P值 | χ2值 | P值 | χ2值 | P值 | χ2值 | P值 | ||
H37Rv | 25.721 | 0.000 | 4.602 | 0.032 | 25.721 | 0.000 | 21.149 | 0.000 | 25.721 | 0.000 | 25.721 | 0.000 | 25.721 | 0.000 | 23.868 | 0.000 | |
H37Ra | 27.212 | 0.000 | 26.103 | 0.000 | 5.223 | 0.022 | 26.769 | 0.000 | 7.703 | 0.006 | 27.039 | 0.000 | 17.607 | 0.000 | 26.145 | 0.000 | |
L1 | - | - | 14.175 | 0.000 | 15.402 | 0.000 | 0.002 | 0.963 | 15.098 | 0.000 | 0.439 | 0.507 | 2.144 | 0.143 | 0.484 | 0.487 | |
P1 | 14.175 | 0.000 | - | - | 26.103 | 0.000 | 15.980 | 0.000 | 26.103 | 0.000 | 18.040 | 0.000 | 17.070 | 0.000 | 14.357 | 0.000 | |
PL1 | 15.402 | 0.000 | 26.103 | 0.000 | - | - | 21.881 | 0.000 | 0.192 | 0.661 | 16.684 | 0.000 | 6.905 | 0.009 | 26.145 | 0.000 | |
PL2 | 0.002 | 0.963 | 15.980 | 0.000 | 21.881 | 0.000 | - | - | 19.102 | 0.000 | 0.208 | 0.648 | 1.475 | 0.225 | 4.356 | 0.037 | |
PL3 | 15.098 | 0.000 | 26.103 | 0.000 | 0.192 | 0.661 | 19.102 | 0.000 | - | - | 16.830 | 0.000 | 5.352 | 0.021 | 23.622 | 0.000 | |
169-1 | 0.439 | 0.507 | 18.040 | 0.000 | 16.684 | 0.000 | 0.208 | 0.648 | 16.830 | 0.000 | - | - | 1.145 | 0.285 | 1.672 | 0.196 | |
169-2 | 2.144 | 0.143 | 17.070 | 0.000 | 6.905 | 0.009 | 1.475 | 0.225 | 5.352 | 0.021 | 1.145 | 0.285 | - | - | 3.600 | 0.058 | |
169-3 | 0.484 | 0.487 | 14.357 | 0.000 | 26.145 | 0.000 | 4.356 | 0.037 | 23.622 | 0.000 | 1.672 | 0.196 | 3.600 | 0.058 | - | - |
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