Abstract:

Objective: To investigate the status of latent tuberculosis infection (LTBI) among elderly rural residents in Changshan County, Zhejiang Province, and its related influencing factors, so as to provide scientific basis for formulating targeted intervention measures. Methods: In the “Tuberculosis Management Information System”, a subsystem of the “China Disease Control Information System”, the towns were sorted by the reported incidence of tuberculosis in the past five years from 2017 to 2021, all the permanent elderly rural residents were selected as the investigation objects in the three villages with the highest reported incidence in Changshan County, Quzhou City, Zhejiang Province, and a total of 909 people were included. Demographic information, smoking history and drinking history were collected. LTBI was detected by interferon gamma-induced protein 10 (IP-10) mRNA release test, and its influencing factors were analyzed by multivariate logistic regression. Results: Among the 909 study subjects, 375 tested positive for LTBI (41.25%) and 534 tested negative (58.75%). Multivariable logistic regression analysis showed that male participants (OR=1.676,95%CI: 1.170-2.401) had a higher risk of LTBI than female participants, while those with higher levels of serum high-density lipoprotein (OR=0.607,95%CI: 0.433-0.852) had a relatively lower risk of LTBI. Conclusion: Elderly rural residents in Changshan County, Zhejiang Province have a high prevalence of LTBI, with particular attention should be paid to males and those with lower levels of high-density lipoprotein.

Key words: Mycobacterium tuberculosis, Infection, Factor analysis, statistics