The role of myeloid system and CD4+T cells in Mycobacterium tuberculosis infection and immunopathology

doi:10.19982/j.issn.1000-6621.20230247

Abstract

Abstract:

Both innate and adaptive immune responses play crucial roles in combating Mycobacterium tuberculosis (MTB) infection, while the development of drug resistance is also correlated with the immune response. It has been revealed that pulmonary myeloid cells mount an immune response against MTB, participating in host protection and contributing to the inflammatory process. Various cell types within the adaptive immune response elicit an immune response against MTB infection, with antigen-specific CD4⁺ T cells playing a major role in controlling the infection. However, in the complex MTB infection environment, different myeloid cells and CD4⁺ T cells may also act as key players in MTB infection, mediating the occurrence of pathological reactions. Therefore, this review aims to summarize the dual role of different myeloid cells (including monocytes, macrophages, dendritic cells) and CD4⁺ T cells in MTB infection.

Key words: Myeloid cells, CD4-positive T-lymphocytes, Mycobacterium tuberculosis, Infection, Defense mechanisms, Review literature as topic

CLC Number:

R52
R392.3

Bi Xiuli, Geng Hong, Jin Jin. The role of myeloid system and CD4⁺T cells in Mycobacterium tuberculosis infection and immunopathology[J]. Chinese Journal of Antituberculosis, 2023, 45(9): 904-912. doi: 10.19982/j.issn.1000-6621.20230247

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The role of myeloid system and CD4⁺T cells in Mycobacterium tuberculosis infection and immunopathology

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