Research status and application progress of mycobacteria phages

doi:10.19982/j.issn.1000-6621.20230171

Abstract

Abstract:

A series of mycobacterial infectious diseases such as tuberculosis, leprosy and Buruli ulcer have become serious problems to be solved urgently, however, the emergence of drug-resistant mycobacteria has intensified the difficulties in the clinical treatment of such diseases. Mycobacteria bacteriophages has great potential in the diagnosis and treatment of mycobacterium diseases. In this paper, the phenotype, genomics and application status of mycobacteria phages were summarized, to provide reference for further research and clinical application of mycobacteria phages.

Key words: Mycobacterium infections, Drug resistance, Mycobacteriophages, Review literature as topic

CLC Number:

R183

Du Yu, Zhang Haipeng, Wang Peng. Research status and application progress of mycobacteria phages[J]. Chinese Journal of Antituberculosis, 2023, 45(9): 897-903. doi: 10.19982/j.issn.1000-6621.20230171

Figures/Tables 2

References 71

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噬菌体名称	宿主细菌	形态	群集	宿主范围
噬菌体名称	宿主细菌	形态	群集	快生型	慢生型
DS6A^[17]	结核分枝杆菌	Siphoviridae	Singleton	-	结核分枝杆菌、牛分枝杆菌、鼠分枝杆菌、卡内分枝杆菌、非洲分枝杆菌
Chy1^[19]	耻垢分枝杆菌	Siphoviridae	-	耻垢分枝杆菌	结核分枝杆菌、牛分枝杆菌
CJAUS9^[20]	耻垢分枝杆菌	Myoviridae	C	耻垢分枝杆菌	-
ZoeJ^[29]	耻垢分枝杆菌	Siphoviridae	K/K2	耻垢分枝杆菌	结核分枝杆菌、鸟分枝杆菌
TM4^[30]	耻垢分枝杆菌	Siphoviridae	K/K2	耻垢分枝杆菌	结核分枝杆菌、鸟分枝杆菌
phiT46-1^[30]	脓肿分枝杆菌	-	-	脓肿分枝杆菌	-
FRAT1^[30]	耻垢分枝杆菌	-	-	耻垢分枝杆菌	卡介苗用牛分枝杆菌
Muddy^[32]	耻垢分枝杆菌	Siphoviridae	AB	耻垢分枝杆菌、脓肿分枝杆菌(GDO1)	-