Research progress of subclinical tuberculosis

doi:10.19982/j.issn.1000-6621.20230159

Abstract

Abstract:

Subclinical tuberculosis is a disease state between latent tuberculosis infection and active tuberculosis. Early detection and intervention of subclinical tuberculosis patients can reduce the risk of developing into active tuberculosis, improve the prognosis, and block the transmission of tuberculosis. This article reviewed domestic and international research progress of subclinical tuberculosis, including the definition, clinical characteristics, transmissibility, pathogenesis, biomarkers, screening and diagnostic methods, in order to identify the current research progress and challenges of subclinical tuberculosis, and provide novel research ideas to accelerate the research on subclinical tuberculosis and exploring more effective tuberculosis prevention and control strategies in China.

Key words: Tuberculosis, Carrier state, Disease attributes, Biological markers, Review literature as topic

CLC Number:

Wang Hanfei, Zhao Yanlin, Xu Caihong. Research progress of subclinical tuberculosis[J]. Chinese Journal of Antituberculosis, 2023, 45(8): 808-813. doi: 10.19982/j.issn.1000-6621.20230159

Figures/Tables 1

References 40

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生物标志物类型	生物标志物作用	生物标志物
基于宿主的转录标志物
新型抗原方面	测量结核病不同疾病阶段方面具有很好的鉴别能力	21种潜伏期特定的RD相关抗原
细胞因子方面	鉴别结核感染后所处的不同阶段	γ-干扰素(IFN-γ)、干扰素诱导蛋白10、白细胞介素-2(IL-2),以及包含白细胞介素类、趋化因子等
细胞亚型方面	区分结核感染不同疾病阶段	结核分枝杆菌特异性T细胞亚群的数目和比例,中性粒细胞、循环单核细胞的表达及与淋巴细胞的比值、NKG2C⁺自然杀伤细胞、多形核髓源性抑制细胞等
基因与表达调控方面	预测结核病进展风险	16个基因转录组风险相关标签:ETV7、FCGR1A、FCGR1B、GBP1、GBP2、GBP5、SCARF1、SERPING1、STAT1和TAP1等;RISK4和双转录本C1QC/TRAV27标签
	区分亚临床结核病和早期结核病;鉴别结核病疾病谱不同阶段	11个基因标记,分别为ABLIM2、C20orf197、CTC-543D15.3、CTD-2503O16.3、HLADRB3、METRNL、RAB11B-AS1、RP4-614C10.2、RNA5SP345、RSU1P1和UACA;还鉴定出一种包含b-FGF、IFN-γ、IL-8RA、IL-1、IL-7p12、IL-70、PDGF-BB和VEGF的8蛋白标签
基于病原体的标志物	评价宿主对感染的反应	痕量游离DNA