Abstract: Objective: To understand the willingness of accepting tuberculosis preventive treatment (TPT) and its influencing factors among patients with latent tuberculosis infection (LTBI) in tuberculosis high-burden areas of Xinjiang Uygur Autonomous Region and to provide evidence for policy making. Methods: A cross-sectional study was conducted to select 3023 patients with tuberculosis confirmed in Awati County and Wushi County, Aksu Prefecture, Xinjiang Uygur Autonomous Region, from August 1, 2021 to December 31, 2022, as index cases, then 6407 close contacts of index cases were screened for LTBI after which 529 LTBI patients were identified. A questionnaire survey was conducted on the willingness of accepting TPT. Information on population characteristics, daily habits, living environment, contact information, health status was collected too. 516 valid questionnaires were retrieved. A binomial-logit linked generalized linear model was constructed to explore the influencing factors. Results: 497 cases were willing to receive TPT, with an acceptance rate of 96.32% (497/516). Those LTBI patients who do not live together with the indicated case were more likely to receive preventive treatment (OR=5.713,95%CI: 1.477-22.097), and those who do not contact other tuberculosis patients except the indicated case were more likely to refuse preventive treatment (OR=0.142,95%CI: 0.039-0.516). Conclusion: LTBI patients among close contacts in high tuberculosis burden areas have a high willingness to receive TPT, which is influenced by their own economic level and contact with tuberculosis patients.

Key words: Mycobacterium tuberculosis, Mycobacterium Infections, Questionnaires, Factor analysis, statistical