Progress of innate immune mechanism activated by Mycobacterium tuberculosis DNA-mediated pattern recognition receptors

doi:10.19982/j.issn.1000-6621.20220399

Abstract

Abstract:

Mycobacterium tuberculosis (MTB) is a major pathogen which cause tuberculosis. Innate immunity plays an important role in the host’s resistance to MTB invasion, and multiple pattern recognition receptors (PRR) in cells are involved in MTB. As the “initiator” of innate immunity, PRR activate innate immunity through signal transduction after recognizing MTB. There are many kinds of MTB components that can be recognized by PRR, including DNA, lipopolysaccharide, protein, etc. This paper focuses on the MTB DNA, from its source, the types of PRR which can recognize MTB DNA, and the mechanism by which PRR uses MTB DNA as a pathogenic-associated molecular pattern to mediate related molecular signaling pathways to activate innate immunity. The process of MTB DNA activating innate immunity via PRR was reviewed in three aspects, and the research progress of the innate immune mechanism activated by PRR such as Toll-like receptor 9, cyclic GMP-AMP synthase and absent in melanoma 2-like receptors was emphatically discussed. At last, the application prospects of MTB DNA were discussed, to expand the development of MTB DNA-related vaccines and the diagnosis of tuberculosis.

Key words: Mycobacterium tuberculosis, DNA, Receptors, pattern recognition, Immunity

CLC Number:

Wang Wenjing, Sun Hong, Sun Zhaogang. Progress of innate immune mechanism activated by Mycobacterium tuberculosis DNA-mediated pattern recognition receptors[J]. Chinese Journal of Antituberculosis, 2023, 45(4): 426-433. doi: 10.19982/j.issn.1000-6621.20220399

Figures/Tables 2

References 73

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可能来源	可识别模式识别受体	参考文献
ESX分泌	cGAS、IFI204	[7,14]
细菌复制或裂解	TLR9、AIM2	[12,15]
囊泡携带	cGAS	[11]