Research progress of chemokines in the diagnosis of tuberculosis

doi:10.19982/j.issn.1000-6621.20220374

Abstract

Abstract:

Chemokines are a family of highly conserved proteins involved in many biological processes, including chemotactic cell migration, immune cell degranulation, hematopoiesis and angiogenesis, and play an important role in the human immune system. After being infected with Mycobacterium tuberculosis, the expression of chemokines and their receptors changes, and many chemokines have the potential to be used as biomarkers for the diagnosis of tuberculosis. The authors summarize the recent studies on chemokines in the diagnosis of tuberculosis, review the diagnostic value of several important chemokines from CC chemokine family, CXC chemokine family, CXCL chemokine family and their receptors, explore the application potential in the diagnosis of tuberculosis and provide valuable clinical reference for the diagnosis and prognosis assessment of tuberculosis in the future.

Key words: Chemokines, Tuberculosis, Diagnosis, Sensitivity and Specificity, Biological Markers

CLC Number:

Ma Zichun, Shang Yuanyuan, Pang Yu, Li Shanshan. Research progress of chemokines in the diagnosis of tuberculosis[J]. Chinese Journal of Antituberculosis, 2023, 45(3): 305-310. doi: 10.19982/j.issn.1000-6621.20220374

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