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中国防痨杂志 ›› 2011, Vol. 33 ›› Issue (7): 434-437.

• 论著 • 上一篇    下一篇

广东省耐多药肺结核预警模型的研究

周琳1  钟球1  刘永奇2  蒋莉1  吴惠忠1   

  1. 1广东省结核病防治研究所; 2华南理工大学自动化科学与工程学院;
  • 收稿日期:2011-02-28 出版日期:2011-07-12 发布日期:2012-03-14
  • 通信作者: 周琳 E-mail:gdtb_bg@vip.163.com
  • 基金资助:

    “十一五”国家重大科技专项(2008ZX10003-007);广东省科技计划项目(2009B030801265);广东省医学科研基金(C2009017)

Study on the early warning model of multidrug resistant tuberculosis in Guangdong province

Zhou Lin1,Zhong Qiu1,Liu Yongqi2,Jiang Li1,Wu Huizhong1   

  1. 1.Anti-tuberculosis Research Institute of Guangdong Province,Guangzhou 510630,China;2.College of Automation Science and Engineering,South China University of Technology,Guangzhou 510640,China
  • Received:2011-02-28 Online:2011-07-12 Published:2012-03-14
  • Contact: Zhou Lin E-mail:gdtb_bg@vip.163.com

摘要: 目的 探索建立适合广东特点的耐多药结核病的预警模型,以期为全省乃至全国耐药、耐多药结核病疫情的控制,国家10年规划的顺利实施提供科学、可靠的理论依据。方法 通过利用控制论的理论知识,用加权平均方法对耐多药结核病死亡率、发现率、治愈率等参数进行估计。建立微分方程。结果 使用现实的参数,模拟和衍生基本再生数(R0)的阈值,构建耐多药肺结核病传播动力学模型。结论 耐多药预警模型的构建及指标校正有赖于完善的耐药性监测资料,作为耐多药肺结核预警模型的初探,将为耐多药结核病防治工作的推进抛砖引玉。

关键词: 结核,肺/预防和控制, 结核,抗多种药物性/预防和控制, 广东省

Abstract: Objective To explore the early warning model of multidrug resistant tuberculosis suit for Guangdong features providing Guangdong province even nationwide with scientific and reliable theory foundation for the MDR-TB control and the implementation of national 10 years plan.Methods Establish the differential equation based on cybernetic theory and the assessment of MDR-TB mortality,detection rate and cure rate though weighted mean method.Results Build the MDR-TB transmission dynamical model with the threshold value of stimulated or derived R0 from real parameter.Conclusion The establishing of warning model of MDR-TB and the indicator adjusting need sophisticated drug resistant monitoring data.As a trying step to MDR-TB warning model,this research did find some clues for the improvement of national MDR-TB control.

Key words: Tuberculosis,pulmonary/prevention &, control, Tuberculosis,multidrug-resistant/prevention &, control, Guangdong province

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